Cell surface proteoglycans are known to be important regulators of many aspects of cell
behavior. The principal family of transmembrane proteoglycans is the syndecans, of which …

In the battle against cancer cells, therapeutic modalities are drastically limited by intrinsic or
acquired drug resistance. Resistance to therapy is not only common, but expected: if …

Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+
influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung …

The tumor microenvironment (TME) is shaped by cancer and noncancerous cells, the
extracellular matrix, soluble factors, and blood vessels. Interactions between the cells …

Calcium is essential for cells to perform numerous physiological processes. In cancer, the
augmentation of calcium signaling supports the more proliferative and migratory cells, which …

Background Among gynecological cancers, ovarian carcinoma has the highest mortality
rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are …

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal interstitial
lung disease of unknown origin. Alveolar epithelial cells (AECs) play an important role in the …

Poly-adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a
posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely …

Recent findings suggest an important role for the dysregulation of stromal interaction
molecule (STIM) proteins, activators of store-operated Ca2+ channels, and the prolonged …

Neuroendocrine prostate cancer (PCa)(NEPC), an aggressive subtype that is associated
with poor prognosis, may arise after androgen deprivation therapy (ADT). We investigated …