Getting to the cores of autism
The genetic architecture of autism spectrum disorder (ASD) is itself a diverse allelic
spectrum that consists of rare de novo or inherited variants in hundreds of genes and …
spectrum that consists of rare de novo or inherited variants in hundreds of genes and …
Beyond comorbidity: Toward a dimensional and hierarchical approach to understanding psychopathology across the life span
MK Forbes, JL Tackett, KE Markon… - Development and …, 2016 - cambridge.org
We propose a novel developmentally informed framework to push research beyond a focus
on comorbidity between discrete diagnostic categories and to move toward research based …
on comorbidity between discrete diagnostic categories and to move toward research based …
Three Approaches to Understanding and Classifying Mental Disorder: ICD-11, DSM-5, and the National Institute of Mental Health's Research Domain Criteria (RDoC)
LA Clark, B Cuthbert… - … Science in the …, 2017 - journals.sagepub.com
The diagnosis of mental disorder initially appears relatively straightforward: Patients present
with symptoms or visible signs of illness; health professionals make diagnoses based …
with symptoms or visible signs of illness; health professionals make diagnoses based …
Quantifying inhibitory control as externalizing proneness: A cross-domain model
Recent mental health initiatives have called for a shift away from purely report-based
conceptualizations of psychopathology toward a biobehaviorally oriented framework. The …
conceptualizations of psychopathology toward a biobehaviorally oriented framework. The …
Redefining the endophenotype concept to accommodate transdiagnostic vulnerabilities and etiological complexity
TP Beauchaine, JN Constantino - Biomarkers in medicine, 2017 - Taylor & Francis
In psychopathology research, endophenotypes are a subset of biomarkers that indicate
genetic vulnerability independent of clinical state. To date, an explicit expectation is that …
genetic vulnerability independent of clinical state. To date, an explicit expectation is that …
Personalized medicine: review and perspectives of promising baseline EEG biomarkers in major depressive disorder and attention deficit hyperactivity disorder
Personalized medicine in psychiatry is in need of biomarkers that resemble central nervous
system function at the level of neuronal activity. Electroencephalography (EEG) during sleep …
system function at the level of neuronal activity. Electroencephalography (EEG) during sleep …
Phenotypic annotation: using polygenic scores to translate discoveries from genome-wide association studies from the top down
Genome-wide association studies (GWASs) have identified specific genetic variants
associated with complex human traits and behaviors, such as educational attainment …
associated with complex human traits and behaviors, such as educational attainment …
[HTML][HTML] The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design
The ABCD twin study will elucidate the genetic and environmental contributions to a wide
range of mental and physical health outcomes in children, including substance use, brain …
range of mental and physical health outcomes in children, including substance use, brain …
The cited quotation, from the fifth (1976) edi
CJ Patrick - Handbook of psychopathy, 2018 - books.google.com
—CLECKLEY (1976, p. 368) toms (“[T] he psychopath is nearly always free from minor
reactions popularly regarded as 'neurotic'or constituting 'nervousness'”; p. 339); and a …
reactions popularly regarded as 'neurotic'or constituting 'nervousness'”; p. 339); and a …
Endophenotypes in psychiatric disease: prospects and challenges
WG Iacono - Genome medicine, 2018 - Springer
Editorial summary Endophenotypes, quantitative neurobehavioral traits that index genetic
susceptibility for a psychiatric disorder, have been examined in thousands of studies …
susceptibility for a psychiatric disorder, have been examined in thousands of studies …