Depression and fatigue are conditions responsible for heavy global societal burden,
especially in patients already suffering from chronic diseases. These symptoms have been …

Because of the compartmentalization of disciplines that shaped the academic landscape of
biology and biomedical sciences in the past, physiological systems have long been studied …

Comorbid depression and chronic pain are highly prevalent in individuals suffering from
physical illness. Here, we critically examine the possibility that inflammation is the common …

Cognitive decline following surgery in older individuals is a major clinical problem of
uncertain mechanism; a similar cognitive decline also follows severe infection …

Cytokine-induced sickness behavior was recognized within a few years of the cloning and
expression of interferon-α, IL-1 and IL-2, which occurred around the time that the first issue …

Anyone who has experienced a viral or bacterial infection knows well the feelings of
sickness, in the form of malaise, lassitude, fatigue, numbness, chills, muscle and joint aches …

BACKGROUND: Inflammatory cytokines are implicated in the pathophysiology of
depression. In rodents, systemically administered inflammatory cytokines induce depression …

I. Introduction THE existence of mechanisms that provide immunity to an infective agent was
inferred from empirical observations obtained through the ingenuity and deductive capacity …

There is a great deal of evidence suggesting an important role for systemic inflammation in
the pathogenesis of A lzheimer's disease. The role of systemic inflammation, and indeed …

▪ Abstract Rapidly accruing evidence from a diversity of disciplines supports the hypothesis
that psychosocial factors are related to morbidity and mortality due to cardiovascular …