Uncovering sex differences of rodent microglia
J Han, Y Fan, K Zhou, K Blomgren… - Journal of …, 2021 - Springer
There are inherent structural and functional differences in the central nervous systems
(CNS) of females and males. It has been gradually established that these sex-specific …
(CNS) of females and males. It has been gradually established that these sex-specific …
Microglia in CNS development: Shaping the brain for the future
Microglial cells are the resident macrophages of the central nervous system (CNS) and are
mainly known for their roles in neuropathologies. However, major recent developments have …
mainly known for their roles in neuropathologies. However, major recent developments have …
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
Microglial activation plays central roles in neuroinflammatory and neurodegenerative
diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein …
diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein …
Maternal inflammation and neurodevelopmental programming: a review of preclinical outcomes and implications for translational psychiatry
SB Gumusoglu, HE Stevens - Biological psychiatry, 2019 - Elsevier
Early disruptions to neurodevelopment are highly relevant to understanding both psychiatric
risk and underlying pathophysiology that can be targeted by new treatments. Much …
risk and underlying pathophysiology that can be targeted by new treatments. Much …
Cholinergic modulation of glial function during aging and chronic neuroinflammation
R Gamage, I Wagnon, I Rossetti, R Childs… - Frontiers in Cellular …, 2020 - frontiersin.org
Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …
Epigenetics control microglia plasticity
Microglia, resident immune cells of the central nervous system, fulfill multiple functions in the
brain throughout life. These microglial functions range from participation in innate and …
brain throughout life. These microglial functions range from participation in innate and …
Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia
Background Microglia are resident myeloid cells in the CNS that are activated by infection,
neuronal injury, and inflammation. Established BV2 microglial cell lines have been the …
neuronal injury, and inflammation. Established BV2 microglial cell lines have been the …
Microglial priming as trained immunity in the brain
In this review we discuss the possibility that the phenomenon of microglial priming can be
explained by the mechanisms that underlie trained immunity. The latter involves the …
explained by the mechanisms that underlie trained immunity. The latter involves the …
Placental macrophages: a window into fetal microglial function in maternal obesity
Fetal placental macrophages and microglia (resident brain macrophages) have a common
origin in the fetal yolk sac. Yolk-sac-derived macrophages comprise the permanent pool of …
origin in the fetal yolk sac. Yolk-sac-derived macrophages comprise the permanent pool of …
White matter injury in the neonatal hypoxic‐ischemic brain and potential therapies targeting microglia
R Shao, D Sun, Y Hu, D Cui - Journal of Neuroscience …, 2021 - Wiley Online Library
Neonatal hypoxic–ischemic (H‐I) injury, which mainly causes neuronal damage and white
matter injury (WMI), is among the predominant causes of infant morbidity (cerebral palsy …
matter injury (WMI), is among the predominant causes of infant morbidity (cerebral palsy …