Valproic acid (VPA), a branched short‐chain fatty acid, is widely used as an antiepileptic
drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of …

Most multi-cellular organisms adopt a specific gene expression pattern during cellular
differentiation. Once established, this pattern is frequently maintained over several cell …

Humans with metabolic and inflammatory diseases frequently harbour lower levels of
butyrate-producing bacteria in their gut. However, it is not known whether variation in the …

SCFAs (short-chain fatty acids), fermentation products of bacteria, influence epithelial-
specific gene expression. We hypothesize that SCFAs affect goblet-cell-specific mucin …

Intrauterine growth retardation (IUGR) has been linked to the onset of diseases in adulthood,
including type 2 diabetes, and has been proposed to result from altered gene regulation …

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased
prevalence and incidence in recent decades. Its etiology remains largely unclear, but it …

Histones undergo several different post-translational modifications that control a variety of
physiological processes. These covalent modifications show substantial cross-regulation …

Chromatin is a complex of DNA, RNA, histones and non-histone proteins and provides the
platform on which the transcriptional machinery operates in eukaryotes. The structure and …

Histone modifications play an important role in epigenetic gene regulation and genome
integrity. It remains largely unknown, however, how these modifications dynamically change …

Methylation of histone H4 at lysine 20 (K20) has been implicated in transcriptional activation,
gene silencing, heterochromatin formation, mitosis, and DNA repair. However, little is known …