COVID-19-associated pulmonary embolism: review of the pathophysiology, epidemiology, prevention, diagnosis, and treatment

L Ortega-Paz, AH Talasaz… - … in thrombosis and …, 2023 - thieme-connect.com
COVID-19 is associated with endothelial activation in the setting of a potent inflammatory
reaction and a hypercoagulable state. The end result of this thromboinflammatory state is an …

Investigational pharmacological agents for the treatment of ARDS

K Aribindi, M Lim, S Lakshminrusimha… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction Acute Respiratory Distress Syndrome (ARDS) is a heterogeneous
form of lung injury with severe hypoxemia and bilateral infiltrates after an inciting event that …

Pharmacotherapy consideration of thrombolytic medications in COVID-19-associated ARDS

S Amini, A Rezabakhsh, J Hashemi, F Saghafi… - Journal of intensive …, 2022 - Springer
Background In late 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) which is responsible for coronavirus disease (COVID-19), was identified as the new …

Causal effects of COVID-19 on the risk of thrombosis: a two-sample Mendel randomization study

Z Li, M Zeng, T Wu, Z Wang, Y Sun… - Thrombosis and …, 2024 - thieme-connect.com
Background Coronavirus disease 2019 (COVID-19) and thrombosis are linked, but the
biomolecular mechanism is unclear. We aimed to investigate the causal relationship …

Efficacy of COVID‐19 Treatments in Intensive Care Unit: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

M Alwakeel, F Abi Fadel, A Nanah… - … Care Research and …, 2024 - Wiley Online Library
Objectives: Examining the cumulative evidence from randomized controlled trials (RCTs),
evaluating the use of pharmacological agents for the treatment of COVID‐19 infections in …

Fibrinolysis in COVID-19: impact on Clot Lysis and Modulation of Inflammation

MA Sugimoto, LO Perucci, LP Tavares… - Current Drug …, 2022 - ingentaconnect.com
COVID-19 is a multisystem disease caused by SARS-CoV-2 and is associated with an
imbalance between the coagulation and fibrinolytic systems. Overall, hypercoagulation …

Role of Fibrinolysis in the Management of Patients with COVID-19 and Thromboembolic Complications: A Review

P Zając, K Kaziród-Wolski, I Oleś, J Sielski… - Journal of …, 2022 - mdpi.com
An impaired fibrinolytic process has been demonstrated in patients infected with SARS-CoV-
2, including those in severe or critical condition. Disruption of fibrinolysis leads to fibrin …

Effectiveness and safety of fibrinolytic therapy in critically ill patients with COVID-19 with ARDS: protocol for a prospective meta-analysis

EH Kovács, F Dembrovszky, K Ocskay, L Szabó… - BMJ open, 2022 - bmjopen.bmj.com
Introduction The use of fibrinolytic therapy has been proposed in severe acute respiratory
distress syndrome (ARDS). During the COVID-19 pandemic, anticoagulation has received …

Fixed-dose ultrasound-assisted catheter-directed thrombolysis for acute pulmonary embolism associated with covid-19

D Voci, S Zbinden, E Micieli, N Kucher, S Barco - Viruses, 2022 - mdpi.com
Background. Fixed-dose ultrasound-assisted catheter-directed thrombolysis (USAT) rapidly
improves hemodynamic parameters and reverses right ventricular dysfunction caused by …

Decreased plasma gelsolin in the COVID-19-related acute respiratory distress syndrome

I Gunturk, GS Seydel, C Yazici… - Turkish Journal of …, 2024 - degruyter.com
Objectives The aim of this study was to evaluate the potential roles of plasma gelsolin
(pGSN), transforming growth factor-beta1 (TGF-β1), and lysophosphatidic acid (LPA) as …