Abstract T helper 17 (TH17) cells have been extensively studied since their discovery 10
years ago, primarily because of their known pathogenic role in many inflammatory diseases …

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

TCR stimulation triggers Ca2+ signals that are critical for T cell function and immunity.
Several pore-forming α and auxiliary β subunits of voltage-gated Ca2+ channels (VGCC) …

Human peripheral blood mononuclear cells (PBMCs) are the key drivers of the immune
responses. These cells undergo activation, proliferation and differentiation into various …

Th cells integrate signals from their microenvironment to acquire distinct specialization
programs for efficient clearance of diverse pathogens or for immunotolerance. Ionic signals …

The serine/threonine-specific Moloney murine leukemia virus (PIM) kinase family (ie, PIM1,
PIM2, and PIM3) has been extensively studied in tumorigenesis. PIM kinases are …

Th17 cells are essential for protection against extracellular pathogens, but their aberrant
activity can cause autoimmunity. Molecular mechanisms that dictate Th17 cell-differentiation …

Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that
regulates many cellular processes. The role of PP2A as a tumor suppressor has been …

T cell activation, proliferation, and differentiation involve metabolic reprogramming resulting
from the interplay of genes, proteins, and metabolites. Here, we aim to understand the …

In addition to carcinogenesis, T helper 17 (Th17) cells (a subtype of CD4+ T lymphocytes)
are involved in the acute, chronic, and cirrhotic phases of liver diseases; however, their role …