Cardiovascular care with digital twin technology in the era of generative artificial intelligence
Digital twins, which are in silico replications of an individual and its environment, have
advanced clinical decision-making and prognostication in cardiovascular medicine. The …
advanced clinical decision-making and prognostication in cardiovascular medicine. The …
Mechanisms and Implications of Electrical Heterogeneity in Cardiac Function in Ischemic Heart Disease
H Martinez-Navarro, X Zhou… - Annual Review of …, 2024 - annualreviews.org
A healthy heart shows intrinsic electrical heterogeneities that play a significant role in
cardiac activation and repolarization. However, cardiac diseases may perturb the baseline …
cardiac activation and repolarization. However, cardiac diseases may perturb the baseline …
In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity, heterogeneity and Purkinje in human
Human-based modelling and simulation offer an ideal testbed for novel medical therapies to
guide experimental and clinical studies. Myocardial infarction (MI) is a common cause of …
guide experimental and clinical studies. Myocardial infarction (MI) is a common cause of …
Quantifying variabilities in cardiac digital twin models of the electrocardiogram
Cardiac digital twins (CDTs) of human cardiac electrophysiology (EP) are digital replicas of
patient hearts that match like-for-like clinical observations. The electrocardiogram (ECG), as …
patient hearts that match like-for-like clinical observations. The electrocardiogram (ECG), as …
Navigating the Evolution of Digital Twins Research through Keyword Co-Occurence Network Analysis
Digital twin technology has become increasingly popular and has revolutionized data
integration and system modeling across various industries, such as manufacturing, energy …
integration and system modeling across various industries, such as manufacturing, energy …
From bits to bedside: entering the age of digital twins in cardiac electrophysiology
Abstract This State of the Future Review describes and discusses the potential
transformative power of digital twins in cardiac electrophysiology. In this 'big …
transformative power of digital twins in cardiac electrophysiology. In this 'big …
[HTML][HTML] Harnessing 12-lead ECG and MRI data to personalise repolarisation profiles in cardiac digital twin models for enhanced virtual drug testing
Cardiac digital twins are computational tools capturing key functional and anatomical
characteristics of patient hearts for investigating disease phenotypes and predicting …
characteristics of patient hearts for investigating disease phenotypes and predicting …
An integrated heart–torso electromechanical model for the simulation of electrophysiological outputs accounting for myocardial deformation
When generating in-silico clinical electrophysiological outputs, such as electrocardiograms
(ECGs) and body surface potential maps (BSPMs), mathematical models have relied on …
(ECGs) and body surface potential maps (BSPMs), mathematical models have relied on …
Cardiac conduction system regeneration prevents arrhythmias after myocardial infarction
JR Sayers, H Martinez-Navarro, X Sun… - Nature Cardiovascular …, 2025 - nature.com
Arrhythmias are a hallmark of myocardial infarction (MI) and increase patient mortality. How
insult to the cardiac conduction system causes arrhythmias following MI is poorly …
insult to the cardiac conduction system causes arrhythmias following MI is poorly …
Fast interactive simulations of cardiac electrical activity in anatomically accurate heart structures by compressing sparse uniform cartesian grids
Abstract Background and Objective: Numerical simulations are valuable tools for studying
cardiac arrhythmias. Not only do they complement experimental studies, but there is also an …
cardiac arrhythmias. Not only do they complement experimental studies, but there is also an …