Dioxygen activation by nonheme diiron enzymes: diverse dioxygen adducts, high-valent intermediates, and related model complexes
AJ Jasniewski, L Que Jr - Chemical Reviews, 2018 - ACS Publications
A growing subset of metalloenzymes activates dioxygen with nonheme diiron active sites to
effect substrate oxidations that range from the hydroxylation of methane and the …
effect substrate oxidations that range from the hydroxylation of methane and the …
Hypusine, a polyamine-derived amino acid critical for eukaryotic translation
MH Park, EC Wolff - Journal of Biological Chemistry, 2018 - ASBMB
The natural amino acid hypusine (N δ-4-amino-2-hydroxybutyl (lysine)) is derived from the
polyamine spermidine, and occurs only in a single family of cellular proteins, eukaryotic …
polyamine spermidine, and occurs only in a single family of cellular proteins, eukaryotic …
Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment
Abstract Hypusine [N ε-(4-amino-2-hydroxybutyl) lysine] is a derivative of lysine that is
formed post-translationally in the eukaryotic initiation factor 5A (eIF5A). Its occurrence at a …
formed post-translationally in the eukaryotic initiation factor 5A (eIF5A). Its occurrence at a …
Emergence of function from nonheme diiron oxygenases: a quantum mechanical/molecular mechanical study of oxygen activation and organophosphonate …
X Song, J Liu, B Wang - ACS Catalysis, 2022 - ACS Publications
Organophosphonate (Pn) catabolism constitutes the major source of inorganic phosphate
(Pi), which is essential for the synthesis of genetic and cellular components. Unlike various …
(Pi), which is essential for the synthesis of genetic and cellular components. Unlike various …
Peroxide activation for electrophilic reactivity by the binuclear non-heme iron enzyme AurF
Binuclear non-heme iron enzymes activate O2 for diverse chemistries that include
oxygenation of organic substrates and hydrogen atom abstraction. This process often …
oxygenation of organic substrates and hydrogen atom abstraction. This process often …
Computational Insights into the Non-Heme Diiron Alkane Monooxygenase Enzyme AlkB: Electronic Structures, Dioxygen Activation, and Hydroxylation Mechanism of …
Y Wang, Y Liu - Inorganic Chemistry, 2024 - ACS Publications
Alkane monooxygenase (AlkB) is a membrane-spanning metalloenzyme that catalyzes the
terminal hydroxylation of straight-chain alkanes involved in the microbially mediated …
terminal hydroxylation of straight-chain alkanes involved in the microbially mediated …
Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI
The final step in the biosynthesis of the antibiotic chloramphenicol is the oxidation of an aryl-
amine substrate to an aryl-nitro product catalyzed by the N-oxygenase CmlI in three two …
amine substrate to an aryl-nitro product catalyzed by the N-oxygenase CmlI in three two …
Sc3+-Promoted O–O Bond Cleavage of a (μ-1,2-Peroxo)diiron(III) Species Formed from an Iron(II) Precursor and O2 to Generate a Complex with an FeIV2(μ-O)2 …
S Banerjee, A Draksharapu… - Journal of the …, 2020 - ACS Publications
Soluble methane monooxygenase (sMMO) carries out methane oxidation at 4° C and under
ambient pressure in a catalytic cycle involving the formation of a peroxodiiron (III) …
ambient pressure in a catalytic cycle involving the formation of a peroxodiiron (III) …
C(sp3)−H Hydroxylation in Diiron β‐Hydroxylase CmlA Transpires by Amine‐Assisted O2 Activation Avoiding FeIV2O2 Species
J Lu, W Lai, H Chen - Angewandte Chemie, 2022 - Wiley Online Library
Through QM/MM modeling, we discovered that C (sp3)− H β‐hydroxylation in the diiron
hydroxylase CmlA transpires by traceless amine‐assisted O2 activation. Different from the …
hydroxylase CmlA transpires by traceless amine‐assisted O2 activation. Different from the …
Emerging structural and functional diversity in proteins with dioxygen-reactive dinuclear transition metal cofactors
LJ Rajakovich, B Zhang, MJ McBride… - … natural products III, 2020 - pure.psu.edu
Molecular oxygen is a powerful oxidant thermodynamically, but its triplet (S ¼ 1) electron-
spin ground state imposes a high kinetic barrier for direct reaction with singlet (S ¼ 0) …
spin ground state imposes a high kinetic barrier for direct reaction with singlet (S ¼ 0) …