Despite strong scientific evidence supporting the benefits of regular exercise for the
prevention and management of cardiovascular disease (CVD), physical inactivity is highly …

The gastrointestinal tract contains trillions of microbes (collectively known as the gut
microbiota) that play essential roles in host physiology and health. Studies from our group …

Background Reduced microbial diversity in human intestines has been implicated in various
conditions such as diabetes, colorectal cancer, and inflammatory bowel disease. The role of …

Skeletal muscle is a highly plastic tissue that plays a central role in human health and
disease. Aging is associated with a decrease in muscle mass and function (sarcopenia) that …

Overweight, obesity, undernutrition and their respective sequelae have devastating tolls on
personal and public health worldwide. Traditional approaches for treating these conditions …

Bacterial-derived lipopolysaccharides (LPS) play an essential role in the inflammatory
process of inflammatory bowel disease. A defective intestinal tight junction (TJ) barrier is an …

Regular aerobic exercise has numerous benefits on human physiology, arguably by serving
as a hormetic stressor resulting in positive adaptations over time. It has long been known …

The microorganisms in the gastrointestinal tract play a significant role in nutrient uptake,
vitamin synthesis, energy harvest, inflammatory modulation, and host immune response …

Sepsis is a common and lethal syndrome: although outcomes have improved, mortality
remains high. No specific anti-sepsis treatments exist; as such, management of patients …

Emerging data indicate that gut-derived endotoxin (metabolic endotoxemia) may contribute
to low-grade systemic inflammation in insulin-resistant states. Specific gut bacteria seem to …