Emerging landscape of cell-penetrating peptide-mediated nucleic acid delivery and their utility in imaging, gene-editing, and RNA-sequencing

J Geng, X Xia, L Teng, L Wang, L Chen, X Guo… - Journal of Controlled …, 2022 - Elsevier
The safety issues like immunogenicity and unacceptable cancer risk of viral vectors for
DNA/mRNA vaccine delivery necessitate the development of non-viral vectors with no …

Progress of delivery methods for CRISPR-Cas9

W Yang, J Yan, P Zhuang, T Ding, Y Chen… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Gene therapy is becoming increasingly common in clinical practice, giving hope
for the correction of a wide range of human diseases and defects. The CRISPR/Cas9 …

Supramolecular peptide nanofiber/PLGA nanocomposites for enhancing pulmonary drug delivery

U Chintapula, S Yang, T Nguyen, Y Li… - … Applied Materials & …, 2022 - ACS Publications
Effective drug delivery to pulmonary sites will benefit from the design and synthesis of novel
drug delivery systems that can overcome various tissue and cellular barriers. Cell …

Cell-penetrating peptides as valuable tools for nose-to-brain delivery of biological drugs

LB De Martini, C Sulmona, L Brambilla, D Rossi - Cells, 2023 - mdpi.com
Due to their high specificity toward the target and their low toxicity, biological drugs have
been successfully employed in a wide range of therapeutic areas. It is yet to be mentioned …

Ionic strength and solution composition dictate the adsorption of cell-penetrating peptides onto phosphatidylcholine membranes

MTH Nguyen, D Biriukov, C Tempra, K Baxova… - Langmuir, 2022 - ACS Publications
Adsorption of arginine-rich positively charged peptides onto neutral zwitterionic
phosphocholine (PC) bilayers is a key step in the translocation of those potent cell …

The endocytic pathway taken by cationic substances requires Rab14 but not Rab5 and Rab7

E Trofimenko, Y Homma, M Fukuda, C Widmann - Cell reports, 2021 - cell.com
Endocytosis and endosome dynamics are controlled by proteins of the small GTPase Rab
family. Besides possible recycling routes to the plasma membrane and various organelles …

Recent advances of studies on cell-penetrating peptides based on molecular dynamics simulations

J Ouyang, Y Sheng, W Wang - Cells, 2022 - mdpi.com
With the ability to transport cargo molecules across cell membranes with low toxicity, cell-
penetrating peptides (CPPs) have become promising candidates for next generation peptide …

[HTML][HTML] Plasma membrane depolarization reveals endosomal escape incapacity of cell-penetrating peptides

M Serulla, P Anees, A Hallaj, E Trofimenko… - European Journal of …, 2023 - Elsevier
Cell-penetrating peptides (CPPs) are short (< 30 amino acids), generally cationic, peptides
that deliver diverse cargos into cells. CPPs access the cytosol either by direct translocation …

Effect of the Lipid Landscape on the Efficacy of Cell-Penetrating Peptides

F Zakany, IM Mándity, Z Varga, G Panyi, P Nagy… - Cells, 2023 - mdpi.com
Every cell biological textbook teaches us that the main role of the plasma membrane is to
separate cells from their neighborhood to allow for a controlled composition of the …

Approaches for evaluation of novel CPP-based cargo delivery systems

L Porosk, Ü Langel - Frontiers in Pharmacology, 2022 - frontiersin.org
Cell penetrating peptides (CPPs) can be broadly defined as relatively short synthetic, protein
derived or chimeric peptides. Their most remarkable property is their ability to cross cell …