Microcins in Enterobacteriaceae: Peptide Antimicrobials in the Eco-Active Intestinal Chemosphere

F Baquero, VF Lanza, MR Baquero… - Frontiers in …, 2019 - frontiersin.org
Microcins are low-molecular-weight, ribosomally produced, highly stable, bacterial-inhibitory
molecules involved in competitive, and amensalistic interactions between …

Bacteriocins to thwart bacterial resistance in gram negative bacteria

S Telhig, L Ben Said, S Zirah, I Fliss… - Frontiers in …, 2020 - frontiersin.org
An overuse of antibiotics both in human and animal health and as growth promoters in
farming practices has increased the prevalence of antibiotic resistance in bacteria. Antibiotic …

What approaches to thwart bacterial efflux pumps-mediated resistance?

AJ Seukep, HG Mbuntcha, V Kuete, Y Chu, E Fan… - Antibiotics, 2022 - mdpi.com
An effective response that combines prevention and treatment is still the most anticipated
solution to the increasing incidence of antimicrobial resistance (AMR). As the phenomenon …

The largely unexplored biology of small proteins in pro‐and eukaryotes

R Steinberg, HG Koch - The FEBS journal, 2021 - Wiley Online Library
The large abundance of small open reading frames (smORFs) in prokaryotic and eukaryotic
genomes and the plethora of smORF‐encoded small proteins became only apparent with …

Microcins reveal natural mechanisms of bacterial manipulation to inform therapeutic development

JK Parker, BW Davies - Microbiology, 2022 - microbiologyresearch.org
Microcins are an understudied and poorly characterized class of antimicrobial peptides.
Despite the existence of only 15 examples, all identified from the Enterobacteriaceae …

Evidence for Widespread Class II Microcins in Enterobacterales Genomes

TJ Cole, JK Parker, AL Feller, CO Wilke… - Applied and …, 2022 - Am Soc Microbiol
Microcins are a class of antimicrobial peptides produced by certain Gram-negative bacterial
species to kill or inhibit the growth of competing bacteria. Only 10 unique, experimentally …

[HTML][HTML] Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli

A Gagarinova, A Hosseinnia, M Rahmatbakhsh… - Nature …, 2022 - nature.com
Bacterial transcription factors (TFs) are widely studied in Escherichia coli. Yet it remains
unclear how individual genes in the underlying pathways of TF machinery operate together …

Class IIb Microcin MccM Interferes with Oxidative Phosphorylation in Escherichia coli

KKA Wang, J Singh, JS Albin, BL Pentelute… - ACS Chemical …, 2024 - ACS Publications
Dysbiosis of the human gut microbiota is linked to numerous diseases. Understanding the
molecular mechanisms by which microbes interact and compete with one another is …

Autoinducer-2 Quorum Sensing Contributes to Regulation of Microcin PDI in Escherichia coli

SY Lu, Z Zhao, JJ Avillan, J Liu, DR Call - Frontiers in microbiology, 2017 - frontiersin.org
The Escherichia coli quorum sensing (QS) signal molecule, autoinducer-2 (AI-2), reaches its
maximum concentration during mid-to-late growth phase after which it quickly degrades …

Implications of quorum sensing and quorum quenching in aquaculture health management

M Jayaprakashvel, R Subramani - Implication of quorum sensing and …, 2019 - Springer
The world human population is growing on an exponential phase and pace. Aquaculture,
raising of aquatic animals in artificial or facilitated ecosystem, is evolving as the rapidly …