Nitroaromatic hypoxia-activated prodrugs for cancer therapy

WA Denny - Pharmaceuticals, 2022 - mdpi.com
The presence of “hypoxic” tissue (with O2 levels of< 0.1 mmHg) in solid tumours, resulting in
quiescent tumour cells distant from blood vessels, but capable of being reactivated by …

Hypoxia induces immunosuppression, metastasis and drug resistance in pancreatic cancers

H Zhang, K Cao, J Xiang, M Zhang, M Zhu, Q Xi - Cancer Letters, 2023 - Elsevier
Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

Hypoxia, a targetable culprit to counter pancreatic cancer resistance to therapy

R Abou Khouzam, JM Lehn, H Mayr, PA Clavien… - Cancers, 2023 - mdpi.com
Simple Summary Hypoxia is a key feature of the tumor microenvironment involved in the
pathogenesis of pancreatic ductal adenocarcinoma (PDAC). In this review we will highlight …

Tyrosine kinase inhibitors and immunotherapy updates in neuroendocrine neoplasms

O Mosalem, MB Sonbol, TR Halfdanarson… - Best Practice & Research …, 2023 - Elsevier
Neuroendocrine tumors (NETs) represent a heterogeneous group of malignancies that arise
from neuroendocrine cells dispersed throughout the organs/tissues of the body. Treatment of …

Chemotherapy in well differentiated neuroendocrine tumors (NET) G1, G2, and G3: a narrative review

A Zappi, I Persano, L Galvani, E Parlagreco… - Journal of Clinical …, 2023 - mdpi.com
Neuroendocrine tumors (NETs) are rare neoplasms with a wide spectrum of clinical
behavior, from the long survival of well-differentiated NETs to the dismal prognosis of high …

Subgrading of G2 pancreatic neuroendocrine tumors as 2A (Ki67 3% to< 10%) versus 2B (10% to≤ 20%) identifies behaviorally distinct subsets in keeping with the …

OC Eren, P Bagci, S Balci, N Ohike, B Saka… - Annals of Surgical …, 2024 - Springer
Abstract Background Grade 1/2 PanNETs are mostly managed similarly, typically without
any adjunct treatment with the belief that their overall metastasis rate is low. In oncology …

Implantable bioresponsive hydrogel prevents local recurrence of breast cancer by enhancing radiosensitivity

Z Fu, H Li, P Xue, H Yu, S Yang, C Tao, W Li… - … in Bioengineering and …, 2022 - frontiersin.org
Breast cancer is one of the most common types of cancer. Patients are often concerned
about regional recurrence after breast cancer surgery. Radiotherapy plays a vital role in …

[HTML][HTML] Risk factors, prognostic predictors, and nomograms for pancreatic cancer patients with initially diagnosed synchronous liver metastasis

BY Cao, F Tong, LT Zhang, YX Kang… - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND Liver metastasis (LM) remains a major cause of cancer-related death in
patients with pancreatic cancer (PC) and is associated with a poor prognosis. Therefore …

Novel therapeutic approaches in GEP-NETs based on genetic and epigenetic alterations

J Pozas, T Alonso-Gordoa, M San Román… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are heterogeneous
malignancies with distinct prognosis based on primary tumor localization, grade, stage and …

Combination systemic therapies in advanced well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs): A comprehensive review of clinical trials …

LN Diamantopoulos, M Kalligeros, TR Halfdanarson… - Biology, 2023 - mdpi.com
Simple Summary This comprehensive review explores evolving systemic combination
regimens for advanced well-differentiated gastroenteropancreatic neuroendocrine tumors …