Bacterial therapies at the interface of synthetic biology and nanomedicine
Bacteria are emerging as living drugs to treat a broad range of disease indications.
However, the inherent advantages of these replicating and immunostimulatory therapies …
However, the inherent advantages of these replicating and immunostimulatory therapies …
Comparing technology and regulatory landscape of probiotics as food, dietary supplements and live biotherapeutics
I Spacova, S Binda, JA Ter Haar, S Henoud… - Frontiers in …, 2023 - frontiersin.org
Application of beneficial microorganisms as probiotics targets a broad range of intended
uses, from maintaining health and supporting normal bodily functions to curing and …
uses, from maintaining health and supporting normal bodily functions to curing and …
Bile acids impact the microbiota, host, and C. difficile dynamics providing insight into mechanisms of efficacy of FMTs and microbiota-focused therapeutics
AS McMillan, CM Theriot - Gut Microbes, 2024 - Taylor & Francis
Clostridioides difficile is a major nosocomial pathogen, causing significant morbidity and
mortality worldwide. Antibiotic usage, a major risk factor for Clostridioides difficile infection …
mortality worldwide. Antibiotic usage, a major risk factor for Clostridioides difficile infection …
Identification of Micrococcin P2-Derivatives as Antibiotic Candidates Against Two Gram-Positive Pathogens
D Kim, J Lee, C Shyaka, JH Kwak, H Pai… - Journal of Medicinal …, 2023 - ACS Publications
Thiopeptides exhibit potent antimicrobial activity against Gram-positive pathogens by
inhibiting bacterial protein synthesis. Micrococcins are among the structurally simpler …
inhibiting bacterial protein synthesis. Micrococcins are among the structurally simpler …
The Urgent Threat of Clostridioides difficile Infection: A Glimpse of the Drugs of the Future, with Related Patents and Prospects
Clostridioides difficile infection (CDI) is an urgent threat and unmet medical need. The
current treatments for CDI are not enough to fight the burden of CDI and recurrent CDI (r …
current treatments for CDI are not enough to fight the burden of CDI and recurrent CDI (r …
Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments
TS Rasmussen, X Mao, S Forster, SB Larsen… - Microbiome, 2024 - Springer
Background Fecal microbiota transplantation (FMT) and fecal virome transplantation (FVT,
sterile filtrated donor feces) have been effective in treating recurrent Clostridioides difficile …
sterile filtrated donor feces) have been effective in treating recurrent Clostridioides difficile …
Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent Clostridioides difficile infection
AS McMillan, G Zhang, MK Dougherty, SK McGill… - Msphere, 2024 - journals.asm.org
Recurrent C. difficile infection (rCDI) is an urgent public health threat, for which the last resort
and lifesaving treatment is a fecal microbiota transplant (FMT). However, the exact …
and lifesaving treatment is a fecal microbiota transplant (FMT). However, the exact …
A profile of the live biotherapeutic product RBX2660 and its role in preventing recurrent Clostridioides difficile infection
T Chopra - Expert Review of Anti-infective Therapy, 2023 - Taylor & Francis
Introduction Clostridiodes difficile infection (CDI) is a life-threatening illness that has been
labelled as an urgent threat by the Centers for Disease prevention (CDC). Areas Covered …
labelled as an urgent threat by the Centers for Disease prevention (CDC). Areas Covered …
Advancements in Novel Live Biotherapeutic Products for Clostridioides difficile Infection Prevention
T Lavoie, HJ Appaneal… - Clinical Infectious Diseases, 2023 - academic.oup.com
The profound impact of the human microbiome on health and disease has captivated the
interest of clinical and scientific communities. The human body hosts a vast array of …
interest of clinical and scientific communities. The human body hosts a vast array of …
Microbiome-Related and Infection Control Approaches to Primary and Secondary Prevention of Clostridioides difficile Infections
LV McFarland, EJC Goldstein, R Kullar - Microorganisms, 2023 - mdpi.com
Clostridioides difficile infections (CDIs) have decreased in the past years, but since 2021,
some hospitals have reported an increase in CDI rates. CDI remains a global concern and …
some hospitals have reported an increase in CDI rates. CDI remains a global concern and …