Background One of the most malignant tumors in men is prostate cancer that is still incurable
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …

The long non-coding RNAs (lncRNAs) are the crucial regulators of human chronic diseases.
Therefore, approaches such as antisense oligonucleotides, RNAi technology, and small …

There is substantial and promising evidence on the health benefits of consuming broccoli
and other cruciferous vegetables. The most important compound in broccoli, glucoraphanin …

Background Studying epigenetics is expected to provide precious information on how
environmental factors contribute to type 2 diabetes mellitus (T2DM) at the genomic level …

Brassicaceae plants are renowned for their taste, aroma and trigeminal characteristics;
predominantly bitter taste, sulfurous aroma, and pungency. Compounds responsible for …

Sulforaphane (SFN), a compound derived from cruciferous vegetables that has been shown
to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its …

Isothicyanates present in cruciferous vegetables are known to exhibit chemoprevention by
various mechanisms. Presently, there is growing evidence that a phytochemical compound …

Epigenetics has provided a new dimension to our understanding of nuclear factor erythroid
2–related factor 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine …

Autophagy degrades non-functioning or damaged proteins and organelles to maintain
cellular homeostasis in a physiological or pathological context. Autophagy can be protective …

Background LncRNA AK044604 (regulator of insulin sensitivity and autophagy, Risa) and
autophagy-related factors Sirt1 and GSK3β play important roles in diabetic nephropathy …