Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …

Pyrazole is a five membered and two-nitrogen containing heterocyclic ring. These structures
have been investigated in the development of novel compounds with hypoglycemic …

Pyrazole, an important pharmacophore and a privileged scaffold of immense significance, is
a five-membered heterocyclic moiety with an extensive therapeutic profile, viz., anti …

The development of new COX-2 inhibitors with analgesic and anti-inflammatory efficacy as
well as minimal gastrointestinal, renal and cardiovascular toxicity, is of vital importance to …

New pyrazole derivatives 2–5 were synthesized and evaluated for their COX-1 and COX-2
inhibitory activity in vitro. All compounds showed good inhibitory activity at a nanomolar level …

Abstract Design, synthesis and pharmacological activities of a group of 1, 3, 5-trisubstituted
pyrazolines were reported. The chemical structures of the synthesized compounds have …

Physicochemical investigation of the red alga Acanthophora spicifera (Vahl) Borgesen,
collected from Al-Shoaiba coast, Red Sea, Saudi Arabia, led to the isolation of a flavone …

New molecular hybrids combining benzothiophene or its bioisostere benzofuran with
rhodanine were synthesized as potential dual COX-2/5-LOX inhibitors. The benzothiophene …

Substituted pyridinium bromides are prepared by conventional and solvent-free greener
methods. The solvent-free solid-phase (greener) method is superior to the conventional …

The anti-inflammatory activities of benzothiazine and pyrazole derivatives are well
documented. A series of novel N′-arylmethylidene-2-(3, 4-dimethyl-5, 5-dioxidopyrazolo (4 …