Does CCL19 act as a double-edged sword in cancer development?

A Gowhari Shabgah, ZMJ Al-Obaidi… - Clinical and …, 2022 - academic.oup.com
Cancer is considered a life-threatening disease, and several factors are involved in its
development. Chemokines are small proteins that physiologically exert pivotal roles in …

Micro-engineering and nano-engineering approaches to investigate tumour ecosystems

M Kim, M Panagiotakopoulou, C Chen, SB Ruiz… - Nature Reviews …, 2023 - nature.com
The interactions among tumour cells, the tumour microenvironment (TME) and non-tumour
tissues are of interest to many cancer researchers. Micro-engineering approaches and …

Integrating multi-omics data through deep learning for accurate cancer prognosis prediction

H Chai, X Zhou, Z Zhang, J Rao, H Zhao… - Computers in biology and …, 2021 - Elsevier
Background Genomic information is nowadays widely used for precise cancer treatments.
Since the individual type of omics data only represents a single view that suffers from data …

[HTML][HTML] Dendritic cell vaccines in breast cancer: Immune modulation and immunotherapy

D Qian, J Li, M Huang, Q Cui, X Liu, K Sun - Biomedicine & …, 2023 - Elsevier
Breast cancer (BC) is the most common cancer in women worldwide. Although substantial
progress has been made in the diagnosis and treatment of breast cancer, the efficacy and …

[HTML][HTML] Immunocompetent cancer-on-chip models to assess immuno-oncology therapy

TI Maulana, E Kromidas, L Wallstabe… - Advanced Drug Delivery …, 2021 - Elsevier
The advances in cancer immunotherapy come with several obstacles, limiting its
widespread use and benefits so far only to a small subset of patients. One of the underlying …

Inflammation-on-a-chip: probing the immune system ex vivo

D Irimia, X Wang - Trends in biotechnology, 2018 - cell.com
Inflammation is the typical result of activating the host immune system against pathogens,
and it helps to clear microbes from tissues. However, inflammation can occur in the absence …

Dendritic cell migration is tuned by mechanical stiffness of the confining space

Y Choi, JE Kwon, YK Cho - Cells, 2021 - mdpi.com
The coordination of cell migration of immune cells is a critical aspect of the immune
response to pathogens. Dendritic cells (DCs), the sentinels of the immune system, are …

Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy

P Shinde, S Fernandes, S Melinkeri, V Kale… - Scientific Reports, 2018 - nature.com
Dendritic cells (DCs) have the potential to elicit long-lasting anti-tumour immune responses.
Most of the clinical trials of anti-cancer DC vaccines are based on monocyte-derived DCs …

Exhausted mature dendritic cells exhibit a slower and less persistent random motility but retain chemotaxis against CCL19

Y Choi, V Sunkara, Y Lee, YK Cho - Lab on a Chip, 2022 - pubs.rsc.org
Dendritic cells (DCs), which are immune sentinels in the peripheral tissues, play a number of
roles, including patrolling for pathogens, internalising antigens, transporting antigens to the …

[HTML][HTML] Increased CCL19 expression is associated with progression in cervical cancer

X Zhang, Y Wang, Y Cao, X Zhang, H Zhao - Oncotarget, 2017 - ncbi.nlm.nih.gov
Cervical cancer is the third most common cancer and the fourth leading cause of malignancy
related mortality in women worldwide. CCL19 is highly expressed in human cancer cells …