DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis

HAJ Schut, EG Snyderwine - Carcinogenesis, 1999 - academic.oup.com
The heterocyclic amines (HCAs) are a family of mutagenic/carcinogenic compounds
produced during the pyrolysis of creatine, amino acids and proteins. The major subclass of …

Pharmacogenetics of the arylamine N-acetyltransferases

NJ Butcher, S Boukouvala, E Sim… - The pharmacogenomics …, 2002 - nature.com
The arylamine N-acetyltransferases (NATs) are involved in the metabolism of a variety of
different compounds that we are exposed to on a daily basis. Many drugs and chemicals …

[图书][B] Fundamentals of Oncology, revised and expanded

HC Pitot - 2002 - taylorfrancis.com
Compiling significant advances from more than a decade of research, this text presents
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …

Metabolism and biomarkers of heterocyclic aromatic amines in humans

M Bellamri, SJ Walmsley, RJ Turesky - Genes and Environment, 2021 - Springer
Heterocyclic aromatic amines (HAAs) form during the high-temperature cooking of meats,
poultry, and fish. Some HAAs also arise during the combustion of tobacco. HAAs are …

Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2

RJ Turesky, A Constable, J Richoz… - Chemical research in …, 1998 - ACS Publications
The dietary mutagens 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline (MeIQx) and 2-
amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) are activated to genotoxins by rat …

Heterocyclic aromatic amine metabolism, DNA adduct formation, mutagenesis, and carcinogenesis

RJ Turesky - Drug metabolism reviews, 2002 - Taylor & Francis
Heterocyclic aromatic amines (HAAs) are carcinogenic compounds formed in meats, fish,
and poultry prepared under common household cooking practices. Some HAAs are also …

Nutrition in adult and childhood cancer: role of carcinogens and anti-carcinogens

TT Mosby, M Cosgrove, S Sarkardei, KL Platt… - Anticancer …, 2012 - ar.iiarjournals.org
There is no doubt that diet is one of the main modifiable risk factors for many degenerative
diseases, including cancer. More than 30% of adult cancers can be prevented or delayed by …

Detection of malondialdehyde DNA adducts in human colorectal mucosa: relationship with diet and the presence of adenomas

C Leuratti, MA Watson, EJ Deag, A Welch… - … Biomarkers & Prevention, 2002 - AACR
Colorectal biopsies from normal mucosa of participants in the United Kingdom Flexible
Sigmoidoscopy Trial and European Prospective Investigation on Cancer (EPIC; n= 162) …

Combined Genotoxic Effects of a Polycyclic Aromatic Hydrocarbon (B(a)P) and an Heterocyclic Amine (PhIP) in Relation to Colorectal Carcinogenesis

EL Jamin, A Riu, T Douki, L Debrauwer, JP Cravedi… - PLoS …, 2013 - journals.plos.org
Colorectal neoplasia is the third most common cancer worldwide. Environmental factors
such as diet are known to be involved in the etiology of this cancer. Several epidemiological …

Chemical carcinogenesis models of cancer: back to the future

MQ McCreery, A Balmain - Annual Review of Cancer Biology, 2017 - annualreviews.org
Over a century has elapsed since the first demonstration that exposure to chemicals in coal
tar can cause cancer in animals. These observations provided an essential causal …