Aims: Human epidermal growth factor receptor 2 (HER2) overexpression/amplification is
implicated in the development of various solid tumour types. Validated methods and scoring …

Abstract c‐erb‐2 amplification and overexpression are currently attracting a great deal of
attention because a new adjuvant therapy using an antibody against the c‐erbB‐2 gene …

Background: The role of human epidermal growth factor receptor (HER) 3 and HER4 has
been elucidated in gastric cancer. HER1 and HER2 overexpression are regarded as …

Background: Epidermal growth factor receptor (EGFR or HER1) and its homolog c-erbB-2
(HER2) are membrane receptors. Both EGFR and HER2 genes are overexpressed in a …

DNA copy number gains and amplifications at 17q are frequent in gastriccancer, yet
systematic analyses of the 17q amplicon have not been performed. In this study, we carried …

AIM: To study the HER-2/neu protein expression and gene amplification in gastric carcinoma
and their relation. METHODS: One hundred and forty-five formalin-fixed and paraffin …

Purpose: Expression levels of insulin-like growth factor type 1 receptor (IGF-IR), epidermal
growth factor receptor (EGFR), and HER2 expressions have been linked to clinical …

Aim To study the HER2 gene amplification or overexpression in patients with advanced
gastric cancer (GC) and their association with patient characteristics and patient survival …

The assessment of human epidermal growth factor receptor 2 (HER2) status in gastric
cancer is crucial in selecting patients who may benefit from targeted therapy, yet …

The various treatments for advanced gastric cancer have limitations and induce only
marginal survival benefit. HER-2/neu protein is overexpressed in several types of human …