Calcium influx can be stimulated by various intra-and extracellular signals to set coordinated
gene expression programs into motion. As such, the precise regulation of intracellular …

Background Gastroesophageal adenocarcinomas (GEAs) are heterogeneous cancers
where immune checkpoint inhibitors have robust efficacy in heavily inflamed microsatellite …

The progress of the cell cycle is directly regulated by modulation of cyclins and cyclin-
dependent kinases. However, many proteins that control DNA replication, RNA transcription …

Objectives An interferon (IFN) gene signature (IGS) is present in approximately 50% of early,
treatment naive rheumatoid arthritis (eRA) patients where it has been shown to negatively …

The inclusion of health-related traits, or functionally associated genetic markers, in pig
breeding programs could contribute to produce more robust and disease resistant animals …

The discovery of humans with monogenic disorders has a rich history of generating new
insights into biology. Here we report the first human identified with complete deficiency of …

The nuclear factor of activated T cells (NFAT) family is well known for the survival of
hemopoietic cells and plays an important role in the immune response. In recent decades …

SALL2 is a poorly characterized transcription factor that belongs to the Spalt‐like family
involved in development. Mutations on SALL2 have been associated with ocular coloboma …

Background Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of
the main toxic species in Parkinson's disease (PD) leading to degeneration. aSyn-O can …

Idiopathic pulmonary fibrosis (IPF) is marked by unremitting matrix deposition and
architectural distortion. Multiple profibrotic pathways contribute to the persistent activation of …