Spatiotemporally programming cytokine immunotherapies through protein engineering

L Santollani, KD Wittrup - Immunological Reviews, 2023 - Wiley Online Library
Cytokines have long been considered promising cancer immunotherapy agents due to their
endogenous role in activating and proliferating lymphocytes. However, since the initial FDA …

Cancer immunotherapy focusing on the role of interleukins; A comprehensive and updated study

M Samadi, A Kamrani, H Nasiri, N Shomali… - … -Research and Practice, 2023 - Elsevier
Cytokines bind to specific receptors on target cells to activate intracellular signaling
pathways that control diverse cellular functions, such as proliferation, differentiation …

Engineering cytokine immunotherapies via cell surface targeting

L Santollani - 2024 - dspace.mit.edu
Cancer immunotherapy targets immune cells to trigger a highly specific, long-lasting anti-
tumor response. With the clinical success of immune checkpoint blockade and the …