The discovery of the E3 ligase cereblon (CRBN) as the target of thalidomide and its analogs
revolutionized the field of targeted protein degradation (TPD). This ubiquitin-mediated …

Acquisition of genomic mutations enables cancer cells to gain fitness advantages under
selective pressure and, ultimately, leads to oncogenic transformation. Interestingly, driver …

This Perspective explores molecular glues and bifunctional compounds—proximity-inducing
compounds—and offers a framework to understand and exploit their similarity to hotspots …