Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

Current anti-seizure drugs fail to control approximately 30% of epilepsies. Therefore, there is
a need to develop more effective anti-seizure drugs, and medicinal plants provide an …

Acute repetitive seizures, also called seizure clusters, are common phenomena in patients
with epilepsy. They are a burden on patients and their caregivers and may be very disruptive …

Objective Epileptogenesis after status epilepticus (SE) has a faster onset in rats treated to
reduce brain levels of the anticonvulsant neurosteroid allopregnanolone with the 5α …

We evaluated the effects of cannabidiol (CBD) on seizures and peroxisome proliferator-
activated receptor gamma (PPARγ) levels in an animal model of temporal lobe epilepsy …

Trilostane is a 3β‐hydroxysteroid dehydrogenase/Δ5‐4 isomerase inhibitor able to produce
a manyfold increase in brain levels of various neurosteroids, including allopregnanolone …

Compounds present in Cannabis sativa L. preparations have recently attracted much
attention in the treatment of drug-resistant epilepsy. Here, we screened two olive oil extracts …

It is known that hippocampal epileptogenesis is accompanied by hyperexcitability, glutamate-
related neuronal dysfunctions and consequently cognitive deficits. However, the …

Abrupt withdrawal from antiepileptic drugs is followed by increased occurrence of epileptic
seizures, a phenomenon known as the “rebound effect”. By stopping treatment with …

Abstract Calcium ions (Ca2+) play crucial roles as second messengers in living cells and
are associated with the onset and development of chronic brain diseases, including …