Enhancer function and evolutionary roles of human accelerated regions
S Whalen, KS Pollard - Annual review of genetics, 2022 - annualreviews.org
Human accelerated regions (HARs) are the fastest-evolving sequences in the human
genome. When HARs were discovered in 2006, their function was mysterious due to scant …
genome. When HARs were discovered in 2006, their function was mysterious due to scant …
Current advances in primate genomics: novel approaches for understanding evolution and disease
Primate genomics holds the key to understanding fundamental aspects of human evolution
and disease. However, genetic diversity and functional genomics data sets are currently …
and disease. However, genetic diversity and functional genomics data sets are currently …
Deep flanking sequence engineering for efficient promoter design using DeepSEED
Designing promoters with desirable properties is essential in synthetic biology. Human
experts are skilled at identifying strong explicit patterns in small samples, while deep …
experts are skilled at identifying strong explicit patterns in small samples, while deep …
The cis-regulatory effects of modern human-specific variants
The Neanderthal and Denisovan genomes enabled the discovery of sequences that differ
between modern and archaic humans, the majority of which are noncoding. However, our …
between modern and archaic humans, the majority of which are noncoding. However, our …
MAP4K4 controlled transcription factor POUM1 regulates PxABCG1 expression influencing Cry1Ac resistance in Plutella xylostella (L.)
L Xu, J Qin, W Fu, S Wang, Q Wu, X Zhou… - Pesticide Biochemistry …, 2022 - Elsevier
Deciphering the molecular mechanisms of insect resistance to Bacillus thuringiensis (Bt)
based biotechnology products including Bt sprays and Bt crops is critical for the long-term …
based biotechnology products including Bt sprays and Bt crops is critical for the long-term …
Chromosomal instability in genome evolution: From cancer to macroevolution
V Comaills, M Castellano-Pozo - Biology, 2023 - mdpi.com
Simple Summary The experimental/pathological observation of genome chaos (including
massive and large-scale translocations, chromothripsis, and polyploidy cancer cells) …
massive and large-scale translocations, chromothripsis, and polyploidy cancer cells) …
Environmentally robust cis-regulatory changes underlie rapid climatic adaptation
Changes in gene expression are thought to play a major role in adaptive evolution. While it
is known that gene expression is highly sensitive to the environment, very few studies have …
is known that gene expression is highly sensitive to the environment, very few studies have …
Applications of advanced technologies for detecting genomic structural variation
Chromosomal structural variation (SV) encompasses a heterogenous class of genetic
variants that exerts strong influences on human health and disease. Despite their …
variants that exerts strong influences on human health and disease. Despite their …
Transcriptomic variations and network hubs controlling seed size and weight during maize seed development
Y Wang, L Nie, J Ma, B Zhou, X Han, J Cheng… - Frontiers in plant …, 2022 - frontiersin.org
To elucidate the mechanisms underlying seed development in maize, comprehensive RNA-
seq analyses were conducted on Zhengdan1002 (ZD1002), Zhengdan958 (ZD958), and …
seq analyses were conducted on Zhengdan1002 (ZD1002), Zhengdan958 (ZD958), and …
Higher order interaction analysis quantifies coordination in the epigenome revealing novel biological relationships in Kabuki syndrome
S Cuvertino, T Garner, E Martirosian… - Briefings in …, 2025 - academic.oup.com
Complex direct and indirect relationships between multiple variables, termed higher order
interactions (HOIs), are characteristics of all natural systems. Traditional differential and …
interactions (HOIs), are characteristics of all natural systems. Traditional differential and …