Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …

The transcription factors STAT1 and STAT3 appear to play opposite roles in tumorigenesis.
While STAT3 promotes cell survival/proliferation, motility and immune tolerance and is …

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a
very poor prognosis. To date patient outcomes have not improved principally due to the …

Immune dysregulation has long been proposed as a component of premature ovarian
insufficiency (POI), but the underlying mediators and mechanisms remain largely unknown …

Pancreatic ductal adenocarcinoma is an aggressive and highly lethal disease frequently
characterized by a dense stromal or desmoplastic response. Accumulating evidence exists …

Chronic pancreatitis/pancreatic cancer (CP/PC) is characterized by fibrous connective tissue
proliferation induced by activated pancreatic stellate cells (PSCs). Galectin-1 is upregulated …

Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich matricellular secreted
protein that regulates diverse cell functions including adhesion, migration, proliferation …

Atlantic salmon smolts challenged intraperitoneally (ip) and by cohabitation with a highly
virulent strain of infectious pancreatic necrosis virus showed strong activation of important …

Aims Autophagy is an intracellular metabolic process that degrades and recycles own
constituents to maintain homeostasis and supply substrates. Disruption of collagen …

Pancreatitis is a severe debilitating disease with high morbidity and mortality. Treatment is
mostly supportive, and until now there are no clinically useful strategies for anti-inflammatory …