Importance Publicly funded mental health services play an important role in addressing co-
occurring mental health problems in children with autism spectrum disorder (ASD); however …

Background Platform trials allow adding new experimental treatments to an on-going trial.
This feature is attractive to practitioners due to improved efficiency. Nevertheless, the …

Background Platform trials improve the efficiency of the drug development process through
flexible features such as adding and dropping arms as evidence emerges. The benefits and …

Background The design of a multi-center randomized controlled trial (RCT) involves multiple
considerations, such as the choice of the sample size, the number of centers and their …

Objective This study examines the impact of training therapists to deliver “An Individualized
Mental Health Intervention for Autism Spectrum Disorder (ASD)”(AIM HI) for children with …

When multiple influential covariates need to be balanced during a clinical trial, stratified
blocked randomization and covariate-adaptive randomization procedures are frequently …

Various restricted randomization procedures are available to achieve equal (1: 1) allocation
in a randomized clinical trial. However, for some procedures, there is a nonnegligible …

Equal randomization has been a popular choice in clinical trial practice. However, in trials
with heterogeneous variances and/or variable treatment costs, as well as in settings where …

An Individualized Mental Health Intervention for ASD (AIM HI) was developed in
collaboration with community stakeholders for delivery in mental health services in response …

In this paper, we present Insertus. jl, the Julia package that can help the user generate a
randomization sequence of a given length for a multi-arm trial with a pre-specified target …