In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

Genomic transcription is fundamental to all organisms. In metazoans, the Integrator complex
is required for endonucleolytic processing of noncoding RNAs, regulation of RNA …

Cellular homeostasis requires transcriptional outputs to be coordinated, and many events
post-transcription initiation can dictate the levels and functions of mature transcripts. To …

The Integrator complex is a multi-subunit protein complex that regulates the processing of
nascent RNAs transcribed by RNA polymerase II (RNAPII), including small nuclear RNAs …

The Integrator complex processes 3′-ends of spliceosomal small nuclear RNAs (snRNAs).
Furthermore, it regulates transcription of protein coding genes by terminating transcription …

Mutations in BRAT1, encoding BRCA1-associated ATM activator 1, have been associated
with neurodevelopmental and neurodegenerative disorders characterized by …

The Integrator complex is conserved across metazoans and controls the fate of many
nascent RNAs transcribed by RNA polymerase II (RNAPII). Among the 14 subunits of …

Mammalian TFEB and TFE3, as well as their ortholog in Caenorhabditis elegans HLH‐30,
play an important role in mediating cellular response to a variety of stress conditions …

Piwi‐interacting RNAs (piRNAs) play key roles in germline development and genome
defence in metazoans. In C. elegans, piRNAs are transcribed from> 15,000 discrete …

The metazoan-specific Integrator complex is a> 1.5 MDa machinery that interacts with RNA
polymerase II (RNAP2) to attenuate coding gene transcription by early termination close to …