Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate
Enediyne natural products are renowned for their potent cytotoxicities but the biosynthesis of
their defining 1, 5-diyne-3-ene core moiety remains largely enigmatic. Since the discovery of …
their defining 1, 5-diyne-3-ene core moiety remains largely enigmatic. Since the discovery of …
Primed for Discovery
Antibiotics are essential components of current medical practice, but their effectiveness is
being eroded by the increasing emergence of antimicrobial-resistant infections. At the same …
being eroded by the increasing emergence of antimicrobial-resistant infections. At the same …
Chalkophomycin Biosynthesis Revealing Unique Enzyme Architecture for a Hybrid Nonribosomal Peptide Synthetase and Polyketide Synthase
L Yang, L Yi, B Gong, L Chen, M Li, X Zhu, Y Duan… - Molecules, 2024 - mdpi.com
Chalkophomycin is a novel chalkophore with antibiotic activities isolated from Streptomyces
sp. CB00271, while its potential in studying cellular copper homeostasis makes it an …
sp. CB00271, while its potential in studying cellular copper homeostasis makes it an …