Understanding immunoregulatory mechanisms is essential for the development of novel
interventions to improve long-term allograft survival. Programmed death 1 (PD-1) and its …

Chronic immunosuppression in solid organ transplant recipients (SOTRs) leads to an
increased risk of a wide variety of cancers. Immune checkpoint inhibitor (ICI) therapy is …

Immune checkpoint inhibitors (ICIs) are widely used for various malignancies. However,
their safety and efficacy in patients with a kidney transplant have not been defined. To …

Background Patients with solid organ transplants (SOTs) have been excluded from
programmed death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) inhibitor clinical …

Antigen-specific immunity requires regulated trafficking of T cells in and out of diverse
tissues in order to orchestrate lymphocyte development, immune surveillance, responses …

Gastric cancer (GC), with a heterogeneous nature, is the third leading cause of death
worldwide. Over the past few decades, stable reductions in the incidence of GC have been …

Therapeutic blockade of PD-1/PD-L1 can have dramatic therapeutic benefit in some
patients; however, the prognostic associations of PD-1 and its ligands, in the absence of …

Although checkpoint inhibitor therapies have demonstrated significant efficacy in many
malignancies, they have not been well studied in patients with a history of solid organ …

We believe that transplant patients can be treated with CPI in a controlled setting and for
well informed patients. To obtain a durable antitumor immune response while avoiding …

Immune regulation is critical for the maintenance of peripheral self-tolerance and for down-
regulation of immune responses. Understanding its mechanisms may permit the …