Two-dimensional and three-dimensional cell culture systems are widely used for biological
studies, and are the basis of the organoid, tissue engineering and organ-on-chip research …

Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

Abstract Three-dimensional (3D) stem cell culture systems have attracted considerable
attention as a way to better mimic the complex interactions between individual cells and the …

Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …

Hydrogels are one of the most commonly explored classes of biomaterials. Their chemical
and structural versatility has enabled their use across a wide range of applications, including …

There is growing appreciation of the role that the extracellular environment plays in
regulating cell behavior. Mechanical, structural, and compositional cues, either alone or in …

In vitro differentiation of human intestinal organoids (HIOs) from pluripotent stem cells is an
unparalleled system for creating complex, multicellular three-dimensional structures capable …

Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic
microorganisms. Because of the complex and long‐term abnormal conditions, osteomyelitis …

Hydrogels are an important class of biomaterials with the unique property of high‐water
content in a crosslinked polymer network. In particular, chemically crosslinked hydrogels …

The key attribute of the thiol-Michael addition reaction that makes it a prized tool in materials
science is its modular “click” nature, which allows for the implementation of this highly …