The formation and maintenance of tissue integrity requires complex, coordinated activities
by thousands of genes and their encoded products. Until recently, transcript levels could …

The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

Recent advances in spatially resolved transcriptomics have greatly expanded the
knowledge of complex multicellular biological systems. The field has quickly expanded in …

The fascinating patterns of collective motion created by autonomously driven particles have
fuelled active-matter research for over two decades. So far, theoretical active-matter …

Understanding tissue structure and function requires tools that quantify the expression of
multiple proteins while preserving spatial information. Here, we describe MIBI-TOF …

The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

DNA nanotechnology has produced a wide range of self-assembled structures, offering
unmatched possibilities in terms of structural design. Because of their programmable …

Spatial transcriptomics technologies developed in recent years can provide various
information including tissue heterogeneity, which is fundamental in biological and medical …

Unravelling spatio-temporal patterns of gene expression is crucial to understanding core
biological principles from embryogenesis to disease. Here we review emerging …

Organelles perform critical biological functions due to their distinct molecular composition
and internal environment. Disorders in organelles or their interacting networks have been …