The immune system is an efficient integrated network of cellular elements and chemicals
developed to preserve the integrity of the organism against external insults and its correct …

The signal transducer and activator of transcription (STAT) proteins have important roles in
biological processes. The abnormal activation of STAT signalling pathways is also …

Pancreatic stellate cells (PSC) are a subset of pancreatic cancer-associated fibroblasts.
These cells provide prosurvival signals to tumors; however, little is known regarding their …

Abstract Signal Transducers and Activators of Transcription (STATs) comprise an important
class of transcription factors that have been implicated in a wide variety of essential cellular …

Melanoma remains among the most lethal cancers and, in spite of great attempts that have
been made to increase the life span of patients with metastatic disease, durable and …

Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …

Myeloid-derived suppressor cells (MDSCs) comprise immature myeloid populations
produced in diverse pathologies, including neoplasia. Because MDSCs can impair …

Background. Obesity is a disorder often accompanied by a heightened state of systemic
inflammation and immunoactivation. The present randomized crossover trial aimed to …

Abstract Signal Transducer and Activator of Transcription (STAT) proteins are a family of
cytoplasmic transcription factors consisting of 7 members, STAT1 to STAT6, including …

Transcription factors have roles at focal points in signaling pathways, controlling many
normal cellular processes, such as cell growth and proliferation, metabolism, apoptosis …