Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Swine is biologically one of the most relevant large animal models for biomedical research.
With its use as food animal that can be exploited as a free cell and tissue source for research …

Heart transplantation is the only long-lasting lifesaving option for patients with terminal
cardiac failure. The number of available human organs is however far below the actual …

Nowadays, safe and efficacious vaccines represent powerful and cost-effective tools for
global health and economic growth. In the veterinary field, these are undoubtedly key tools …

Renal transplantation is the preferred treatment of ESKD, but the shortage of suitable donor
kidneys from the cadaver pool means that many patients with ESKD will not receive a kidney …

T cells are an essential component of the adaptive immune system. Over the last 15 years, a
constantly growing toolbox with which to study T cell biology in pigs has allowed detailed …

Foot-and-mouth disease (FMD) is a serious disease affecting the global graziery industry.
Once an epidemic occurs, it can lead to economic and trade stagnation. In recent decades …

Advances in genetic engineering, particularly CRISPR/Cas9, have resulted in the
development of a triple glycan-knockout (TKO) pig. There is minimal human antipig antibody …

CD4+ T cells are an integral component of the adaptive immune response, carrying out
many functions to combat a diverse range of pathogenic challenges. These cells exhibit …