Modeling of heterogeneous materials and media is a problem of fundamental importance to
a wide class of phenomena and systems, ranging from condensed matter physics, soft …

Wet granulation is a key step in the pharmaceutical manufacturing of solid-dosage forms.
Wet granulation is used in pharmaceutical production to enhance formulation qualities such …

Process simulation using mathematical modeling tools is becoming more common in the
pharmaceutical industry. A mechanistic model is a mathematical modeling tool that can …

Wet granulation is a very important unit operation that finds applications in many industries
mainly pharmaceutical and chemical industries. Various granulation technologies in batch …

High shear wet granulation (HSWG) is considered a complicated and multivariate
pharmaceutical process that is influenced by a large number of variables derived from …

Current trends in pharmaceutical wet granulation have been shifted from traditional
approach to systematic and modern approaches, enabling the production of highly …

Abstract A coupled CFD-DEM and Monte Carlo approach was developed to investigate
coating properties in a Wurster fluidized bed by considering gas flow, particle motion, droplet …

The implementation of continuous pharmaceutical manufacturing requires advanced control
strategies rather than traditional end product testing or an operation within a small range of …

This paper presents surrogate models of dissolution behavior to identify the critical input
parameters in tablet manufacturing processes. Dissolution behavior is a critical quality …

Wet fluidized bed granulation and coating processes have been widely used in the
pharmaceutical and food industries. The complex gas–solid flow coupled with heat and …