Nasally inhaled therapeutics and vaccination for COVID‐19: Developments and challenges

J Xi, LR Lei, W Zouzas, X April Si - MedComm, 2021 - Wiley Online Library
The nose is the initial site of viral infection, replication, and transmission in the human body.
Nasally inhaled vaccines may act as a promising alternative for COVID‐19 management in …

The yielding behaviour of human mucus

D Kavishvar, A Ramachandran - Advances in Colloid and Interface Science, 2023 - Elsevier
Mucus is a viscoelastic material with non-linear rheological properties such as yield stress of
the order of a few hundreds of millipascals to a few tens of pascals, due to a complex …

Miniaturized metachronal magnetic artificial cilia

Z Cui, Y Wang, S Zhang, T Wang… - Proceedings of the …, 2023 - National Acad Sciences
Biological cilia, hairlike organelles on cell surfaces, often exhibit collective wavelike motion
known as metachrony, which helps generating fluid flow. Inspired by nature, researchers …

[HTML][HTML] Cystic fibrosis and primary ciliary dyskinesia: Similarities and differences

R Pereira, T Barbosa, AL Cardoso, R Sá, M Sousa - Respiratory medicine, 2023 - Elsevier
Cystic fibrosis (CF) and Primary ciliary dyskinesia (PCD) are both rare chronic diseases,
inherited disorders associated with multiple complications, namely respiratory …

The potential role and regulatory mechanisms of MUC5AC in chronic obstructive pulmonary disease

J Li, Z Ye - Molecules, 2020 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is associated with high morbidity and
mortality globally. Studies show that airway mucus hypersecretion strongly compromises …

Goblet cell interactions reorient bundled mucus strands for efficient airway clearance

MF Bos, A Ermund, GC Hansson, J de Graaf - PNAS nexus, 2023 - academic.oup.com
The respiratory tract of larger animals is cleared by sweeping bundled strands along the
airway surface. These bundled strands can be millimetric in length and consist of MUC5B …

From static to dynamic: a review on the role of mucus heterogeneity in particle and microbial transport

DD Pednekar, MA Liguori, CNH Marques… - ACS Biomaterials …, 2022 - ACS Publications
Mucus layers (McLs) are on the front line of the human defense system that protect us from
foreign abiotic/biotic particles (eg, airborne virus SARS-CoV-2) and lubricates our organs …

Nanotechnology-Based Drug Delivery Systems to Control Bacterial-Biofilm-Associated Lung Infections

Y Guo, Z Mao, F Ran, J Sun, J Zhang, G Chai, J Wang - Pharmaceutics, 2023 - mdpi.com
Airway mucus dysfunction and impaired immunological defenses are hallmarks of several
lung diseases, including asthma, cystic fibrosis, and chronic obstructive pulmonary …

On the role of viscoelasticity in mucociliary clearance: a hydrodynamic continuum approach

A Choudhury, M Filoche, NM Ribe… - Journal of Fluid …, 2023 - cambridge.org
We present numerical and analytical predictions of mucociliary clearance based on the
continuum description of a viscoelastic mucus film, where momentum transfer from the …

A review of computational modeling of fluid-immersed flexible filaments

Divyaprakash, M Garg, A Kumar… - Journal of the Indian …, 2024 - Springer
Hydrodynamics of slender flexible filaments plays an important role in biology, human
physiology, locomotion of organisms, as well as biomedical devices. It is, therefore …