Previous studies have demonstrated a bidirectional relationship between inflammation and
depression. Activation of the nucleotide-binding oligomerization domain, leucine-rich repeat …

Major depression is a significant medical issue impacting millions of individuals worldwide.
Identifying factors contributing to its manifestation has been a subject of intense investigation …

Decreased estrogens during menopause are associated with increased risk of anxiety,
depression, type 2 diabetes and obesity. Similarly, depleting estrogens in rodents by …

The ability to track animals accurately is critical for behavioral experiments. For video-based
assays, this is often accomplished by manipulating environmental conditions to increase …

The utility of mouse and rat studies critically depends on their replicability in other
laboratories. A widely advocated approach to improving replicability is through the rigorous …

Women who have bilateral oophorectomies prior to the age of natural menopause are at
increased risk of developing mild cognitive decline, dementia, anxiety, and depressive type …

Despite substantial evidence for sex differences in addiction epidemiology, addiction‐
relevant behaviors and associated neurobiological phenomena, the mechanisms and …

Postpartum estrogen (E2) withdrawal is known to be a particularly vulnerable time for
depressive symptoms. In this study, ovariectomized (OVX) mice were treated with co …

Anxiety is a prominent and debilitating symptom in Alzheimer's disease (AD) patients.
Carriers of APOE4, the greatest genetic risk factor for late-onset AD, may experience …

Parent-of-origin effects (POE) in mammals typically arise from maternal effects or imprinting.
In some instances, such POE have been associated with psychiatric disorders, as well as …