Severe hemorrhage has posed a serious threat to the health and even life of civilian and
military populations and brought serious economic losses. Consequently, it is imperative to …

Hemorrhage is the most common cause of death both in hospitals and on the battlefield. The
need for an effective hemostatic agent remains, since all injuries are not amenable to …

Intracranial haemorrhage (ICH) is the most serious event in haemophiliacs, resulting in high
rates of mortality and disability. Although the use of a prophylaxis regimen has improved …

Background The safety and efficacy of craniotomy, endoscopic surgery, and stereotactic
aspiration for surgical evacuation of spontaneous supratentorial lobar intracerebral …

Factor XIII (FXIII) is activated by thrombin to form a transglutaminase (FXIIIa) that stabilizes
clot formation by the cross‐linking of fibrin monomers and antifibrinolytic proteins. Although …

Introduction Emicizumab has been shown to be safe and effective for prevention of bleeds in
patients with severe haemophilia A (SHA), both with and without inhibitors. The …

Bruising or bleeding in a child can raise the concern for child abuse. Assessing whether the
findings are the result of trauma and/or whether the child has a bleeding disorder is critical …

Intracerebral hemorrhage (ICH) is the most dreaded complication, and the main cause of
death, in patients with congenital bleeding disorders. ICH can occur in all congenital …

Intracranial hemorrhage (ICH), as a life-threatening bleeding among all kinds of congenital
bleeding disorders (CBDs), is a rare manifestation except in factor XIII (FXIII) deficiency …

Congenital Factor XIII (FXIII) deficiency is a rare, inherited, autosomal recessive coagulation
disorder. Most mutations of this condition are found in the A-subunit with almost half these …