Lipid–drug conjugates (LDCs) are drug molecules that have been covalently modified with
lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes …

Squalene is a natural lipid belonging to the terpenoid family and a precursor of cholesterol
biosynthesis. It is synthesized in humans and also in a wide array of organisms and …

Future nanoscale soft matter design will be guided to a large extent by the teachings of
amphiphile (lipid or surfactant) self-assembly. Ordered nanostructured lyotropic liquid …

Gemcitabine is an antimetabolite ranking among the most prescribed anticancer drugs
worldwide. This nucleoside analog exerts its antiproliferative action after tumoral conversion …

There are numerous anticancer agents based on a prodrug approach. However, no attempt
has been made to review the ample available literature with a specific focus on the altered …

One-component nanomedicine (OCN) represents an emerging class of therapeutic
nanostructures that contain only one type of chemical substance. This one-component …

Nanomedicine employs nanotechnologies to develop innovative applications, and more
specifically nano-objects in the field of human health, through exploitation of the physical …

Nanomedicines suffer from poor drug loading and uncontrolled 'burst release'after
administration. Combining prodrug strategies with nanostructured carriers can help to …

This study reports the design of a novel theragnostic nanomedicine which combines (i) the
ability to target a prodrug of gemcitabine to an experimental solid tumor under the influence …

Squalene is a triterpene widely distributed in nature that is an intermediate in the cholesterol
biosynthesis pathway. The remarkable dynamic folded conformation of squalene has been …