Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus
pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate …

Wall teichoic acid (WTA) and lipoteichoic acid (LTA) are structural components of Gram-
positive bacteria's peptidoglycan and cell membrane, which are mostly anionic …

Ticlopidine is an anti-platelet drug which belongs to the thienopyridine structural family and
exerts its effect by functioning as an ADP receptor inhibitor. Ticlopidine inhibits the …

Lipoteichoic acid synthase (LtaS) is a key enzyme for the cell wall biosynthesis of Gram-
positive bacteria. Gram-positive bacteria that lack lipoteichoic acid (LTA) exhibit impaired …

Isoquinoline alkaloids are a large group of natural products in which 1, 2, 3, 4-
tetrahydroisoquinolines (THIQ) form an important class. THIQ based natural and synthetic …

The major surface polysaccharides of Staphylococcus aureus include the capsular
polysaccharide (CP), cell wall teichoic acid (WTA), and polysaccharide intercellular …

This article reviews the structures and biological activities of several classes of uridine-
containing nucleoside antibiotics (tunicamycins, mureidomycins/pacidamycins …

The practice of medicine was profoundly transformed by the introduction of the antibiotics
(compounds isolated from Nature) and the antibacterials (compounds prepared by …

Bacterial adhesion to the skin and mucosa is often a fundamental and early step in host
colonization, the establishment of bacterial infections, and pathology. This process is …

Methicillin-resistant Staphylococcus aureus (MRSA) is a medical concern. Here, we show
that branched polyethylenimine (BPEI), a nontoxic, cationic polymer, restores MRSA's …