History, global distribution, and nutritional importance of citrus fruits

YQ Liu, E Heying… - Comprehensive reviews in …, 2012 - Wiley Online Library
Although the mysteries of its history and origin remain unsolved, worldwide cultivation and
high‐demand production for citrus fruit (genus Citrus in family Rutaceae) make it stand high …

A systematic review of carotenoids in the management of age-related macular degeneration

DW Lem, PG Davey, DL Gierhart, RB Rosen - Antioxidants, 2021 - mdpi.com
Age-related macular degeneration (AMD) remains a leading cause of modifiable vision loss
in older adults. Chronic oxidative injury and compromised antioxidant defenses represent …

Intakes of lutein, zeaxanthin, and other carotenoids and age-related macular degeneration during 2 decades of prospective follow-up

J Wu, E Cho, WC Willett, SM Sastry… - JAMA …, 2015 - jamanetwork.com
Importance Despite strong biological plausibility, evidence from epidemiologic studies and
clinical trials on the relations between intakes of lutein and zeaxanthin and age-related …

Absorption, metabolism, and functions of β-cryptoxanthin

BJ Burri, MR La Frano, C Zhu - Nutrition reviews, 2016 - academic.oup.com
Abstract β-Cryptoxanthin, a carotenoid found in fruits and vegetables such as tangerines,
red peppers, and pumpkin, has several functions important for human health. Most evidence …

[HTML][HTML] Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration

E Kersten, CC Paun, RL Schellevis, CB Hoyng… - survey of …, 2018 - Elsevier
Biomarkers can help unravel mechanisms of disease and identify new targets for therapy.
They can also be useful in clinical practice for monitoring disease progression, evaluation of …

Carotenoid metabolites, their tissue and blood concentrations in humans and further bioactivity via retinoid receptor-mediated signalling

T Bohn, AR de Lera, JF Landrier… - Nutrition Research …, 2023 - cambridge.org
Many epidemiological studies have emphasised the relation between carotenoid dietary
intake and their circulating concentrations and beneficial health effects, such as lower risk of …

Geographic atrophy in patients with advanced dry age-related macular degeneration: current challenges and future prospects

RP Danis, JA Lavine, A Domalpally - Clinical Ophthalmology, 2015 - Taylor & Francis
Geographic atrophy (GA) of the retinal pigment epithelium (RPE) is a devastating
complication of age-related macular degeneration (AMD). GA may be classified as drusen …

Discovering the potential of natural antioxidants in age-related macular degeneration: a review

KH Wong, HY Nam, SY Lew, M Naidu, P David… - Pharmaceuticals, 2022 - mdpi.com
Age-related macular degeneration (AMD) is a multifactorial disease associated with
anatomical changes in the inner retina. Despite tremendous advances in clinical care, there …

Double-loaded liposomes encapsulating lycopene β-cyclodextrin complexes: Preparation, optimization, and evaluation

S Jhan, AM Pethe - Journal of liposome research, 2020 - Taylor & Francis
In the present investigation, we attempted to develop a lycopene-in-β-CD-in-phospholipid
vesicles (LCPV) with the sole aim of combining the solubilizing power of β-CD with the …

Visual function and macular carotenoid changes in eyes with retinal drusen—An open label randomized controlled trial to compare a micronized lipid-based …

PG Davey, T Henderson, DW Lem, R Weis… - Nutrients, 2020 - mdpi.com
Purpose: To compare the changes in visual and ocular parameters in individuals with retinal
drusen who were treated with two commercially available nutritional supplements. Methods …