The impact of molecular dynamics (MD) simulations in molecular biology and drug discovery
has expanded dramatically in recent years. These simulations capture the behavior of …

Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …

The drug discovery process is a rocky path that is full of challenges, with the result that very
few candidates progress from hit compound to a commercially available product, often due …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Carbohydrate partitioning is the process of carbon assimilation and distribution from source
tissues, such as leaves, to sink tissues, such as stems, roots and seeds. Sucrose, the …

A fundamental challenge in biological research is achieving an atomic-level description and
mechanistic understanding of the function of biomolecules. Techniques for biomolecular …

Despite the relevance of seed‐filling mechanisms for crop yield, we still have only a
rudimentary understanding of the transport processes that supply the caryopsis with sugars …

Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across
biological membranes. Dysregulation of SLCs has been associated with various …

Key message Present review describes the structure, evolution, transport mechanism and
physiological functions of SWEETs. Their application using TALENs and CRISPR/CAS9 …

Large-scale conformational changes are essential to link protein structures with their
function at the cell and organism scale, but have been elusive both experimentally and …