▪ Abstract The GoLoco motif is a 19-amino-acid sequence with guanine nucleotide
dissociation inhibitor activity against G-alpha subunits of the adenylyl-cyclase-inhibitory …

▪ Abstract Accessory proteins involved in signal processing through heterotrimeric G proteins
are generally defined as proteins distinct from G protein–coupled receptor (GPCR), G …

Chronic cocaine administration reduces G protein signaling efficacy. Here, we report that the
expression of AGS3, which binds to GiαGDP and inhibits GDP dissociation, was upregulated …

Activation of trimeric G proteins has been traditionally viewed as the exclusive job of G
protein-coupled receptors (GPCRs). This view has been challenged by the discovery of non …

Signal processing via heterotrimeric G-proteins in response to cell surface receptors is a
central and much investigated aspect of how cells integrate cellular stimuli to produce …

The identification of AGS proteins as receptor-independent activators of G-protein signaling
reveals unexpected mechanisms for the regulation of heterotrimeric G-protein activation and …

Canonical signal transduction via heterotrimeric G proteins is spatially and temporally
restricted, that is, triggered exclusively at the plasma membrane (PM), only by agonist …

Effective medical treatment of opiate addiction is limited by a high relapse rate in abstinent
addicts. Opiate withdrawal causes cAMP superactivation, but the underlying molecular …

As part of a broader effort to identify postreceptor signal regulators involved in specific
diseases or organ adaptation, we used an expression cloning system in Saccharomyces …

Heterotrimeric G proteins are critical signal-transducing molecules controlled by a complex
network of regulators. GIV (aka Girdin) is a unique component of this network and a …