In silico and in vitro studies for benzimidazole anthelmintics repurposing as VEGFR-2 antagonists: novel mebendazole-loaded mixed micelles with enhanced …
Cancer is a leading cause of death worldwide and its incidence is unfortunately anticipated
to rise in the next years. On the other hand, vascular endothelial growth factor receptor 2 …
to rise in the next years. On the other hand, vascular endothelial growth factor receptor 2 …
Investigating the structure–activity relationship of marine natural polyketides as promising SARS-CoV-2 main protease inhibitors
Since its first report in December 2019, the novel coronavirus virus, SARS-CoV-2, has
caused an unprecedented global health crisis and economic loss imposing a tremendous …
caused an unprecedented global health crisis and economic loss imposing a tremendous …
Computational and Biological Evaluation of β-Adrenoreceptor Blockers as Promising Bacterial Anti-Virulence Agents
Bacterial resistance to antibiotics is an increasing public health threat as it has the potential
to affect people at any stage of life, as well as veterinary. Various approaches have been …
to affect people at any stage of life, as well as veterinary. Various approaches have been …
In Silico Designing of a Multitope Vaccine against Rhizopus microsporus with Potential Activity against Other Mucormycosis Causing Fungi
During the current era of the COVID-19 pandemic, the dissemination of Mucorales has been
reported globally, with elevated rates of infection in India, and because of the high rate of …
reported globally, with elevated rates of infection in India, and because of the high rate of …
Integration of Chemoinformatics and Multi-Omics Analysis Defines ECT2 as a Potential Target for Cancer Drug Therapy
Simple Summary Cancer is a leading cause of death worldwide and continuous efforts are
exerted to develop novel biomarkers and therapeutic agents that could help in early …
exerted to develop novel biomarkers and therapeutic agents that could help in early …
Phenolics from Chrozophora oblongifolia Aerial Parts as Inhibitors of α-Glucosidases and Advanced Glycation End Products: In-Vitro Assessment, Molecular Docking …
HM Abdallah, AT Kashegari, AA Shalabi, KM Darwish… - Biology, 2022 - mdpi.com
Simple Summary The chemical investigation of Chrozophora oblongifolia aerial parts
resulted in the isolation of five phenolic compounds. The isolated metabolites were tested for …
resulted in the isolation of five phenolic compounds. The isolated metabolites were tested for …
Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development
The opioid crisis in the United States is a significant public health issue, with a nearly
threefold increase in opioid-related fatalities between 1999 and 2014. In response to this …
threefold increase in opioid-related fatalities between 1999 and 2014. In response to this …
In silico Designing of an Epitope-Based Vaccine Against Common E. coli Pathotypes
MA Soltan, MY Behairy, MS Abdelkader… - Frontiers in …, 2022 - frontiersin.org
Escherichia coli (E. coli) is a Gram-negative bacterium that belongs to the family
Enterobacteriaceae. While E. coli can stay as an innocuous resident in the digestive tract, it …
Enterobacteriaceae. While E. coli can stay as an innocuous resident in the digestive tract, it …
Mechanistic characterization of the pharmacological profile of HS-731, a peripherally acting opioid analgesic, at the µ-, δ-, κ-opioid and nociceptin receptors
Accumulated preclinical and clinical data show that peripheral restricted opioids provide
pain relief with reduced side effects. The peripherally acting opioid analgesic HS-731 is a …
pain relief with reduced side effects. The peripherally acting opioid analgesic HS-731 is a …
Deciphering Molecular Aspects of Potential α-Glucosidase Inhibitors within Aspergillus terreus: A Computational Odyssey of Molecular Docking-Coupled Dynamics …
Hyperglycemia, as a hallmark of the metabolic malady diabetes mellitus, has been an
overwhelming healthcare burden owing to its high rates of comorbidity and mortality, as well …
overwhelming healthcare burden owing to its high rates of comorbidity and mortality, as well …