Members of the seven-transmembrane receptor (7TMR), or G protein-coupled receptor
(GPCR), superfamily represent some of the most successful targets of modern drug therapy …

Heptahelical G protein-coupled receptors are the most diverse and therapeutically important
family of receptors in the human genome. Ligand binding activates heterotrimeric G proteins …

We used μCT and histomorphometry to assess age‐related changes in bone architecture in
male and female C57BL/6J mice. Deterioration in vertebral and femoral trabecular …

The effects of caloric restriction (CR) on the skeleton are well studied in adult rodents and
include lower cortical bone mass but higher trabecular bone volume. Much less is known …

Heterotrimeric G protein–coupled receptors (GPCRs) are found on the surface of all cells of
multicellular organisms and are major mediators of intercellular communication. More than …

Parathyroid hormone (PTH) regulates calcium homeostasis via the type I PTH/PTH-related
peptide (PTH/PTHrP) receptor (PTH1R). The purpose of the present study was to identify the …

Periostin (gene Postn) is a secreted extracellular matrix protein involved in cell recruitment
and adhesion and plays an important role in odontogenesis. In bone, periostin is …

About 40% of the therapeutic agents in use today exert their effects through seven-
transmembrane receptors (7TMRs). When activated by ligands, these receptors trigger two …

Periostin (Postn) is a matricellular protein preferentially expressed by osteocytes and
periosteal osteoblasts in response to mechanical stimulation and parathyroid hormone …

Changes in whole body energy levels are closely linked to alterations in body weight and
bone mass. Here, we show that hypothalamic signals contribute to the regulation of bone …