Experimental autoimmune uveoretinitis (EAU) serves as an animal model for human uveitis.
EAU is inducible in animals by peripheral immunization with proteins found in the retina that …

Autoimmune disorders are characterized by a loss of immune tolerance and consequent
autoimmunity-mediated disease manifestation. Experimental models are invaluable …

Experimental autoimmune uveoretinitis (EAU), a widely used animal model of human
posterior/pan-uveitis, is extremely valuable in allowing understanding of the pathogenesis of …

purpose. The aims of this study were to determine whether IL-17+ T cells were present in
CD4 and CD8 interphotoreceptor retinoid-binding protein (IRBP)-specific T cells and to …

We show that in vitro activation of interphotoreceptor retinoid-binding protein (IRBP)-specific
T cells from C57BL/6 mice immunized with an uveitogenic IRBP peptide (IRBP 1–20) under …

Background Controversy exists regarding which cell types are responsible for autoantigen
presentation in the retina during experimental autoimmune uveitis (EAU) development. In …

IL-17-producing CD4+ T helper 17 (Th17) cells are pathogenic in a range of human
autoimmune diseases and corresponding animal models. We now demonstrate that such T …

Long non-coding RNAs (lncRNAs) interaction with RNA-Binding proteins (RBPs) plays an
important role in immunological processes. The generation of antigen-specific Th17 cells is …

Mesenchymal stem cells (MSCs) exhibit a potent immunomodulatory capacity and have
been applied to treat diseases such as graft versus host disease and severe autoimmune …

Pathogenic Th17 cells drive autoimmune pathology, but the molecular mechanisms
underlying Th17 pathogenicity remain poorly understood. Here, we have shown that miR …