Mechanisms of fibrosis development in nonalcoholic steatohepatitis

RF Schwabe, I Tabas, UB Pajvani - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, affecting 20%–
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …

Natural products as a source for antifibrosis therapy

DQ Chen, YL Feng, G Cao, YY Zhao - Trends in pharmacological sciences, 2018 - cell.com
Although fibrosis is a final pathological feature of many chronic diseases, few interventions
are available that specifically target the pathogenesis of fibrosis. Natural products are …

Hedgehog signalling in liver pathophysiology

MV Machado, AM Diehl - Journal of hepatology, 2018 - Elsevier
Liver disease remains a leading cause of mortality worldwide despite recent successes in
the field of viral hepatitis, because increases in alcohol consumption and obesity are fuelling …

The role of MDM2–p53 axis dysfunction in the hepatocellular carcinoma transformation

H Cao, X Chen, Z Wang, L Wang, Q Xia… - Cell Death Discovery, 2020 - nature.com
Liver cancer is the second most frequent cause of cancer-related death globally. The main
histological subtype is hepatocellular carcinoma (HCC), which is derived from hepatocytes …

Anti-miR-96 and Hh pathway inhibitor MDB5 synergistically ameliorate alcohol-associated liver injury in mice

V Kumar, B Sethi, DW Staller, X Xin, J Ma, Y Dong… - Biomaterials, 2023 - Elsevier
Alcohol-associated liver disease (ALD) and its complications are significant health problems
worldwide. Several pathways in ALD are influenced by alcohol that drives inflammation, fatty …

Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2

Y Jiang, J Peng, J Song, J He, M Jiang, J Wang… - Nature …, 2021 - nature.com
Abstract The Hedgehog (Hh) signalling pathway plays a critical role in regulating liver lipid
metabolism and related diseases. However, the underlying mechanisms are poorly …

Hepatic protective effects of Shenling Baizhu powder, a herbal compound, against inflammatory damage via TLR4/NLRP3 signalling pathway in rats with nonalcoholic …

M Pan, C Zheng, Y Deng, K Tang, H Nie, J Xie… - Journal of Integrative …, 2021 - Elsevier
Objective High-fat diet (HFD) and inflammation are two key contributors to nonalcoholic fatty
liver disease (NAFLD). Shenling Baizhu powder (SLBZP), a classical herbal compound, has …

Shenling Baizhu powder alleviates non-alcoholic fatty liver disease by modulating autophagy and energy metabolism in high-fat diet-induced rats

M Pan, Y Deng, Y Qiu, D Pi, C Zheng, Z Liang, J Zhen… - Phytomedicine, 2024 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) has emerged as a burgeoning health
problem worldwide, but no specific drug has been approved for its treatment. Shenling …

p53 as a double-edged sword in the progression of non-alcoholic fatty liver disease

Z Yan, X Miao, B Zhang, J Xie - Life sciences, 2018 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) derives from the accumulation of hepatic lipids,
which leads to liver steatosis and then triggers non-alcoholic steatohepatitis, sometimes …

Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles

T He, N Lykov, X Luo, H Wang, Z Du, Z Chen… - International Journal of …, 2023 - mdpi.com
Fatty liver is one of the most pervasive liver diseases worldwide. Probiotics play an important
role in the progression of liver disease, but their effects on host regulation are poorly …