The vitamin A metabolite all-trans-retinoic acid (RA) regulates multiple biological processes
by virtue of its ability to regulate gene expression. It thus plays critical roles in embryonic …

Oral isotretinoin (13-cis retinoic acid) is the most effective drug in the treatment of acne and
restores all major pathogenetic factors of acne vulgaris. Isotretinoin is regarded as a prodrug …

BACKGROUND & AIMS: Gut-associated dendritic cells (DC) metabolize vitamin A into all-
trans retinoic acid (RA), which is required to induce lymphocytes to localize to the …

Retinoic acid (RA) displays pronounced anticarcinogenic activities in several types of
cancer. Whereas the mechanisms that underlie this activity remain incompletely understood …

The anticarcinogenic activities of retinoic acid (RA) are believed to be mediated by the
nuclear RA receptor (RAR) and by the RA-binding protein cellular RA-binding protein-II …

Abstract Treatment of glioblastoma (GBM), as the most lethal type of brain tumor, still
remains a major challenge despite the various therapeutic approaches developed over the …

Experiments with sciatic nerve lesions and spinal cord contusion injury demonstrate that the
retinoic acid (RA) signaling cascade is activated by these traumatic events. In both cases the …

Hematological malignancies (HM) represent a subset of neoplasms affecting the blood,
bone marrow, and lymphatic systems, categorized primarily into leukemia, lymphoma, and …

Magnolol (MG) and honokiol (HK), two lignans showing anti-inflammatory and anti-oxidant
properties and abundantly available in the medicinal plants Magnolia officinalis and M …

OBJECTIVE: The standard of care for promyelocytic leukemia includes use of the
differentiating agent all-trans retinoic acid (RA) and chemotherapy. RA induces cell …