Antimicrobial peptides (AMPs): a patent review (2015–2020)

G Annunziato, G Costantino - Expert Opinion on Therapeutic …, 2020 - Taylor & Francis
Introduction: Antimicrobial peptides are a large class of compounds that are part of innate
immune response found among all classes of life and are considered promising compounds …

A bird's-eye view of enzyme evolution: chemical, physicochemical, and physiological considerations

D Davidi, LM Longo, J Jabłońska, R Milo… - Chemical …, 2018 - ACS Publications
Enzymes catalyze a vast range of reactions. Their catalytic performances, mechanisms,
global folds, and active-site architectures are also highly diverse, suggesting that enzymes …

Nitrogen sourcing during viral infection of marine cyanobacteria

JR Waldbauer, ML Coleman, AI Rizzo… - Proceedings of the …, 2019 - National Acad Sciences
The building blocks of a virus derived from de novo biosynthesis during infection and/or
catabolism of preexisting host cell biomass, and the relative contribution of these 2 sources …

Engineering Escherichia coli for efficient glutathione production

H Mori, M Matsui, T Bamba, Y Hori, S Kitamura… - Metabolic …, 2024 - Elsevier
Glutathione is a tripeptide of excellent value in the pharmaceutical, food, and cosmetic
industries that is currently produced during yeast fermentation. In this case, glutathione …

Combatting antimicrobial resistance via the cysteine biosynthesis pathway in bacterial pathogens

JL Hicks, KEA Oldham, J McGarvie… - Bioscience …, 2022 - portlandpress.com
Antibiotics are the cornerstone of modern medicine and agriculture, and rising antibiotic
resistance is one the biggest threats to global health and food security. Identifying new and …

Increasing 2-furfurylthiol content in Chinese sesame-flavored Baijiu via inoculating the producer of precursor l-cysteine in Baijiu fermentation

T Shen, J Liu, Q Wu, Y Xu - Food Research International, 2020 - Elsevier
Furfurylthiol was an important contributor to the flavor of traditional fermented foods
including Baijiu. It is essential to increase 2-furfurylthiol concentration to improve the quality …

Unraveling the essential role of CysK in CDI toxin activation

PM Johnson, CM Beck, RP Morse… - Proceedings of the …, 2016 - National Acad Sciences
Contact-dependent growth inhibition (CDI) is a widespread mechanism of bacterial
competition. CDI+ bacteria deliver the toxic C-terminal region of contact-dependent …

Characterization of the O-acetylserine(thiol)lyase gene family in Solanum lycopersicum L.

D Liu, J Lu, H Li, J Wang, Y Pei - Plant molecular biology, 2019 - Springer
Key message This research demonstrated the conservation and diversification of the
functions of the O-acetylserine-(thiol) lyase gene family genes in Solanum lycopersicum L …

Investigational Studies on a Hit Compound Cyclopropane–Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant

G Annunziato, C Spadini, N Franko… - ACS infectious …, 2021 - ACS Publications
Antibacterial adjuvants are of great significance, since they allow the therapeutic dose of
conventional antibiotics to be lowered and reduce the insurgence of antibiotic resistance …

Advancements in inhibitors of crucial enzymes in the cysteine biosynthetic pathway: Serine acetyltransferase and O‐acetylserine sulfhydrylase

Y Qin, Y Teng, Y Yang, Z Mao, S Zhao… - Chemical Biology & …, 2024 - Wiley Online Library
Infectious diseases have been jeopardized problem that threaten public health over a long
period of time. The growing prevalence of drug‐resistant pathogens and infectious cases …