Morpholine as ubiquitous pharmacophore in medicinal chemistry: Deep insight into the structure-activity relationship (SAR)
A Kumari, RK Singh - Bioorganic Chemistry, 2020 - Elsevier
Morpholine is a versatile moiety, a privileged pharmacophore and an outstanding
heterocyclic motif with wide ranges of pharmacological activities due to different …
heterocyclic motif with wide ranges of pharmacological activities due to different …
Recent advances in the development of broad-spectrum antiprotozoal agents
A Moreno-Herrera, S Cortez-Maya… - Current Medicinal …, 2021 - ingentaconnect.com
Infections caused by Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp.,
Entamoeba histolytica, Giardia lamblia, Plasmodium spp., and Trichomonas vaginalis, are …
Entamoeba histolytica, Giardia lamblia, Plasmodium spp., and Trichomonas vaginalis, are …
Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities
Methylbenzimidazole 1–28 novel derivatives were synthesized and evaluated for their
antiglycation and antioxidant activities. Compounds 1–7 and 11 showed excellent activities …
antiglycation and antioxidant activities. Compounds 1–7 and 11 showed excellent activities …
Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α-glucosidase and urease inhibition potential
Compounds 1–30 showed varying degree of α-glucosidase inhibition with IC 50 values
ranging between 187 and 420 μ M. Compounds 1, 2, 3, 6, 8, 12, and 4 (IC 50= 187.7±3.05 …
ranging between 187 and 420 μ M. Compounds 1, 2, 3, 6, 8, 12, and 4 (IC 50= 187.7±3.05 …
[PDF][PDF] Emphasizing morpholine and its derivatives (maid): typical candidate of pharmaceutical importance
K Rupak, SR Vulichi, K Suman - Int. J. Chem. Sci, 2016 - researchgate.net
The use of chemicals (drugs) for both medical and recreational purposes is hardly new. In
fact, drug use seems to have been a part of human science prehistory. Morpholine …
fact, drug use seems to have been a part of human science prehistory. Morpholine …
Molecular hybridization conceded exceptionally potent quinolinyl-oxadiazole hybrids through phenyl linked thiosemicarbazide antileishmanial scaffolds: In silico …
The high potential of quinoline containing natural products and their derivatives in medicinal
chemistry led us to discover a novel series of compounds 6–23 based on the concept of …
chemistry led us to discover a novel series of compounds 6–23 based on the concept of …
Synthesis and molecular modelling studies of phenyl linked oxadiazole-phenylhydrazone hybrids as potent antileishmanial agents
Molecular hybridization yielded phenyl linked oxadiazole-benzohydrazones hybrids 6–35
and were evaluated for their antileishmanial potentials. Compound 10, a 3, 4-dihydroxy …
and were evaluated for their antileishmanial potentials. Compound 10, a 3, 4-dihydroxy …
Imidazo[1,2-a]pyrimidine as a New Antileishmanial Pharmacophore against Leishmania amazonensis Promastigotes and Amastigotes
R Kumar, R Singh, A das Chagas Almeida… - ACS …, 2023 - ACS Publications
Leishmania poses a substantial threat to the human population all over the globe because
of its visceral and cutaneous spread engendered by all 20 species. Unfortunately, the …
of its visceral and cutaneous spread engendered by all 20 species. Unfortunately, the …
In Vitro and in Vivo Antileishmanial and Trypanocidal Studies of New N-Benzene- and N-Naphthalenesulfonamide Derivatives
C Galiana-Rosello, P Bilbao-Ramos… - Journal of medicinal …, 2013 - ACS Publications
We report in vivo and in vitro antileishmanial and trypanocidal activities of a new series of N-
substituted benzene and naphthalenesulfonamides 1–15. Compounds 1–15 were screened …
substituted benzene and naphthalenesulfonamides 1–15. Compounds 1–15 were screened …
Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors
Phenoxyacetohydrazide Schiff base analogs 1–28 have been synthesized and their in vitro
β-glucouoronidase inhibition potential studied. Compounds 1 (IC50= 9.20±0.32 µM), 5 …
β-glucouoronidase inhibition potential studied. Compounds 1 (IC50= 9.20±0.32 µM), 5 …