The role of the insulin-like growth factor-1 system in breast cancer
IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the
cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti …
cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti …
Common genetic variation and breast cancer risk—past, present, and future
J Lilyquist, KJ Ruddy, CM Vachon, FJ Couch - … Epidemiology, Biomarkers & …, 2018 - AACR
Breast cancer is the most common cancer among women in the United States, with up to
30% of those diagnosed displaying a family history of breast cancer. To date, 18% of the …
30% of those diagnosed displaying a family history of breast cancer. To date, 18% of the …
Breast cancer risk prediction using a clinical risk model and polygenic risk score
Breast cancer risk assessment can inform the use of screening and prevention modalities.
We investigated the performance of the Breast Cancer Surveillance Consortium (BCSC) risk …
We investigated the performance of the Breast Cancer Surveillance Consortium (BCSC) risk …
Breast cancer risk factors and their effects on survival: a Mendelian randomisation study
M Escala-Garcia, A Morra, S Canisius, J Chang-Claude… - BMC medicine, 2020 - Springer
Background Observational studies have investigated the association of risk factors with
breast cancer prognosis. However, the results have been conflicting and it has been …
breast cancer prognosis. However, the results have been conflicting and it has been …
Mendelian randomization analyses of 23 known and suspected risk factors and biomarkers for breast cancer overall and by molecular subtypes
Many risk factors have been identified for breast cancer. The potential causality for some of
them remains uncertain, and few studies have comprehensively investigated these …
them remains uncertain, and few studies have comprehensively investigated these …
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170
We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen
receptor α) in 118,816 subjects from three international consortia. We found evidence for at …
receptor α) in 118,816 subjects from three international consortia. We found evidence for at …
Improved methods for multi-trait fine mapping of pleiotropic risk loci
Motivation Genome-wide association studies (GWAS) have identified thousands of regions
in the genome that contain genetic variants that increase risk for complex traits and …
in the genome that contain genetic variants that increase risk for complex traits and …
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
Variation in body fat distribution contributes to the metabolic sequelae of obesity. The
genetic determinants of body fat distribution are poorly understood. The goal of this study …
genetic determinants of body fat distribution are poorly understood. The goal of this study …
Integrated molecular landscape of Parkinson's disease
CJHM Klemann, GJM Martens, M Sharma… - npj Parkinson's …, 2017 - nature.com
Parkinson's disease is caused by a complex interplay of genetic and environmental factors.
Although a number of independent molecular pathways and processes have been …
Although a number of independent molecular pathways and processes have been …
Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants
Known risk variants explain only a small proportion of breast cancer heritability, particularly
in Asian women. To search for additional genetic susceptibility loci for breast cancer, here …
in Asian women. To search for additional genetic susceptibility loci for breast cancer, here …